H. Eugene Hoyme, MD | Medical Genetics | Sanford Health Skip To Content

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H. Eugene Hoyme, MD


  • Medical School
    University of Chicago, Pritzker School of Medicine
  • Residency
    Pediatric Residency from the University of California, San Diego School of Medicine
  • Fellowship
    Fellowship in Clinical Genetics and Dysmorphology from the University of California, San Diego School of Medicine
  • Board Certifications
    Certified in General Pediatrics by the American Board of Pediatrics; and in Clinical Genetics and Clinical Cytogenetics by the American Board of Medical Genetics

Medical Genetics

Dr. Hoyme is the chief of genetics and genomic medicine and chief academic officer for Sanford Health. He is also a professor of pediatrics (Medical Genetics) at the Sanford School of Medicine of the University of South Dakota. He served as president of Sanford Research from 2011-2014.

From 2007-2011, he served as chair of the Department of Pediatrics of the Sanford School of Medicine. Previously, he held academic appointments and leadership posts at the Stanford School of Medicine, Palo Alto, the University of Arizona College of Medicine, Tucson, and the University of Vermont College of Medicine, Burlington.

Dr. Hoyme is internationally known for his work with fetal alcohol spectrum disorders and has held numerous leadership roles in regional and national clinical and research organizations in pediatrics and medical genetics. He has led fetal alcohol syndrome research studies in South Africa for the past 15 years and helped establish the prevalence rate of fetal alcohol syndrome in South Africa, which remains the highest documented rate in the world.

In 2011, he was the recipient of the Western Society of Pediatric Research’s Joseph W. St. Geme Jr. Education Award in recognition of outstanding achievement in pediatric education; and in 2012, Dr. Hoyme was the recipient of the National Organization on Fetal Alcohol Syndrome Excellence Award, joining the ranks of almost 40 past recipients that include Senator John McCain and the late Ted Kennedy.

His research focuses on the delineation of genetic syndromes and fetal alcohol spectrum disorders. His interest in fetal alcohol spectrum disorders has concentrated on practical, accurate and early diagnosis of affected children. He has authored 140 original articles and 25 book chapters, monographs and electronic publications, the majority of which focus on fetal alcohol spectrum disorders. He is the co-author of the recently published textbook Signs and Symptoms of Genetic Disease, by Oxford University Press.


Additional Practice Locations

Sanford Children's Hospital

1600 W 22nd Street
Sioux Falls, SD 57117-5039

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(605) 312-1000

Sanford Children's Specialty Clinic

1600 W 22nd Street
Sioux Falls, SD 57117

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(605) 312-1000
(800) 850-0064


(605) 312-1001