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Pregnancy Screening Tests

Sanford's Fetal Care Center specialists perform an array of screenings to diagnosis or rule out suspected fetal congenital birth defects or chromosomal abnormalities.

It is a personal decision whether or not you decide to perform testing. Testing cannot identify all birth defects. Your fetal care provider will discuss each recommended test with you.


Sanford's Ultrasound Diagnostic Center provides advanced ultrasound screening for high-risk pregnancies. Our sonographers are highly trained to help identify, confirm or rule out fetal abnormalities and track fetal development and growth throughout all stages of pregnancy.

Sanford's Ultrasound Diagnostic Center is accredited by the American Institute of Ultrasound in Medicine - having met and exceeded their strict standards for advanced technique, training and continuing education. All of our high-risk patients receive ultrasound screenings, which are performed by a registered sonographer and read and interpreted by our Fetal Care specialists.

First Trimester Screening

A blood test that screens for a higher risk of Down's Syndrome, Trisomy 18, congenital heart defects and other birth defects. Performed between weeks 11 and 13 in pregnancy.

Genetic amniocentesis

Tests the fluid around the fetus to identify chromosomal or genetic abnormalities. Amniocentesis is 99 percent accurate in detecting chromosomal abnormalities and 90 percent for neural tube defects.

Lung maturity amniocentesis

Tests the fluid surrounding your baby to determine lung development.

PUBS (cordocentesis)

Tests a sample of umbilical blood to diagnose abnormalities. Commonly performed on twins.

Non-invasive prenatal diagnosis (NIPD)

A blood screening test for women after 10 weeks of pregnancy to test for chromosomal abnormalities including trisomy 18, Down syndrome and trisomy 13.

Chorionic villus sampling

Tests for chromosomal abnormalities in a sample of chorionic villi from the placenta.

Second trimester screening (quad screen)

Screens for chromosome abnormalities such as Down Syndrome, Trisomy 18, Smith-Lemli-Opitz Syndrome or a Neural Tube defect such as Spina Bifada. Performed between 15 – 20 weeks in pregnancy.

Antenatal testing

Screens newborns for 30 genetic conditions within the first week after birth. Routinely performed. Some of these conditions include cystic fibrosis, sickle cell anemia and phenylketonuria (PKU).