Randomized Placebo-Controlled Trial of Hydroxychloroquine as Post-Exposure Prophylaxis against COVID-19 Infection

Title: PEPCOH: Post-Exposure Prophylaxis for COVID-19 with Hydroxychloroquine Description: This is a research study looking at whether the drug hydroxychloroquine can help prevent an individual from getting sick after they have been exposed to someone who tested positive for COVID-19. This trial is not for people who already have COVID-19. Instead, this trial focuses on health care workers or individuals who are considered high-risk, who may have been exposed at work or in the community. People enrolled in the trial will be given either hydroxychloroquine or a placebo. Although this drug is getting national attention, its effectiveness in preventing or treating COVID-19 is unknown until clinical trials take place. 4 Key Inclusion/Exclusion Criteria including Age Range If Applicable: • Exposed to someone with a confirmed COVID-19 positive test within the past 5 days • No current COVID-19 symptoms (fever, cough, difficulty breathing, sore throat) • Must be at least 18 years old • Meet one of the following criteria: - Employees of any health care organization in South Dakota, with direct patient contact - Any Sanford Health employee with direct patient contact, regardless of state - Residents of South Dakota, regardless of health care provider who have one or more risk factors* - Any patient of Sanford Health, regardless of state, with one or more risk factors* *Risk factors include congestive heart failure, asthma, COPD, emphysema, organ transplant, currently on immunosuppressive drugs such as chemotherapy, kidney disease, cardiovascular disease such as hypertension, smoking or vaping, obesity, high cholesterol or over 80 years of age.
Fargo Region, Sioux Falls Region
Principal Investigator:
Susan Hoover, MD,Avish Nagpal, MD
Active - Open to Accrual