Study will explore biomarkers, early detection of juvenile diabetes
(Sioux Falls, SD) – The Juvenile Diabetes Research Foundation (JDRF) has awarded The Sanford Project’s Zhiguang Guo, MD, PhD, a three-year, $750,000 grant to study biomarkers that could earlier indicate the onset of juvenile (type 1) diabetes.
Guo’s study is titled “Identification and Validation of Beta Cell Biomarkers in Humanized Mouse Models with Functional Human Islets.”
The Sanford Project is an emerging translational research center focused on targeted diabetes research, cures and care made possible in part through the generosity of Denny Sanford.
Type 1 diabetes is characterized by a loss of beta cells, which create insulin. This loss, however, can be difficult to detect in its early stages. Using a mouse model, Guo and his research team will work to identify biomarkers that correlate with the early loss of beta cells. The mouse model will include human islet grafts, which maintain beta cell production.
“Success in these experiments could help develop a panel of biomarkers for clinical evaluation of type 1 diabetes stages,” said Dr. Guo. “Further, this could help start early therapeutic interventions to effectively protect remaining beta cell mass and to prevent or delay the onset of type 1 diabetes.”
Dr. Guo, who also received a $500,000 grant from the JDRF in August, is a scientist with The Sanford Project at Sanford Research.
JDRF is the leading global organization funding type 1 diabetes (T1D) research. It currently sponsors $568 million in scientific research in 17 countries.
About Sanford Research
Sanford Research is a non-profit research organization and is part of Sanford Health, an integrated health system headquartered in Fargo, ND and Sioux Falls, SD. Sanford represents the largest, rural, not-for-profit health care system in the nation with a presence in 111 communities, nine states and two countries. In 2007, a transformational gift of $400 million by Denny Sanford provided for an expansion of children’s and research initiatives, one of which was to find a cure for type 1 diabetes, and has given Sanford Research significant momentum in its goal of becoming one of the premiere research institutions in the United States and the world. Most recently, subsequent gifts of more than $200 million by Mr. Sanford have paved the way to establish Edith Sanford Breast Cancer Research and Sanford Imagenetics.
With a team of more than 200 researchers, Sanford Research comprises several research centers, including Children’s Health Research, Edith Sanford Breast Cancer, Cancer Biology, Center for Health Outcomes and Prevention, Sanford Applied Biosciences, and the Sanford Sports Science Institute.
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