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vorinostat

Pronunciation: vor IN o stat

Brand: Zolinza

What is the most important information I should know about vorinostat?

Multum donot

You should not use this medication if you are allergic to vorinostat, or if you have severe liver disease.

Multum nopreg

Do not use vorinostat if you are pregnant. It could harm the unborn baby.

Multum nobrfeed

You should not breast-feed while you are using vorinostat.

Multum water

Drink at least 2 liters of water each day to keep from getting dehydrated while you are taking vorinostat. Tell your doctor if you have severe vomiting or diarrhea during treatment.

Multum nocrush

Do not crush or open a vorinostat capsule. Swallow it whole. The medicine inside the capsule can be dangerous if it gets in your eyes, mouth, or nose, or on your skin. If this occurs, wash your skin with soap and water or rinse your eyes with water. Ask your doctor or pharmacist how to safely handle and dispose of a broken tablet or capsule.

Multum emt

You may need regular medical tests to be sure this medication is not causing harmful effects. Visit your doctor regularly.

Multum donot

Stop using vorinostat and call your doctor at once if you have chest pain, sudden cough, wheezing, rapid breathing, coughing up blood, swelling or warmth in one or both legs, fever, chills, mouth sores, easy bruising or bleeding, bloody or tarry tools, or severe vomiting or diarrhea.

What is vorinostat?

Vorinostat is used to treat skin problems caused by cutaneous T-cell lymphoma.

Vorinostat is usually given after other treatments have been tried without successful treatment.

Vorinostat may also be used for purposes not listed in this medication guide.

What should I discuss with my health care provider before taking vorinostat?

Multum donot

You should not use this medication if you are allergic to vorinostat, or if you have severe liver disease.

To make sure vorinostat is safe for you, tell your doctor if you have any of these other conditions:

  • diabetes;
  • liver disease;
  • kidney disease;
  • anemia (low red blood cells);
  • an electrolyte imbalance (such as high or low potassium levels in your blood);
  • a personal or family history of Long QT syndrome;
  • a history of stroke or blood clot; or
  • if you have recently been ill with vomiting or diarrhea.
Multum nopreg

FDA pregnancy category D. Do not use vorinostat if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

Multum nobrfeed

It is not known whether vorinostat passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using vorinostat.

How should I take vorinostat?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Your doctor may occasionally change your dose to make sure you get the best results. Follow the directions on your prescription label.

Multum food

Vorinostat is usually taken once daily with food.

Multum water

Drink at least 2 liters of water each day to keep from getting dehydrated while you are taking vorinostat. Tell your doctor if you have severe vomiting or diarrhea during treatment.

Multum nocrush

Do not crush or open a vorinostat capsule. Swallow it whole. The medicine inside the capsule can be dangerous if it gets in your eyes, mouth, or nose, or on your skin. If this occurs, wash your skin with soap and water or rinse your eyes with water. Ask your doctor or pharmacist how to safely handle and dispose of a broken capsule.

Multum emt

You will need regular medical tests to be sure this medication is not causing harmful effects. Visit your doctor regularly.

Multum rt

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe forms of some of the side effects listed in this medication guide.

What should I avoid while taking vorinostat?

Avoid becoming overheated or dehydrated during exercise and in hot weather.

What are the possible side effects of vorinostat?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Multum donot

Stop using vorinostat and call your doctor at once if you have a serious side effect such as:

  • chest pain, sudden cough, wheezing, rapid breathing;
  • pain, swelling, warmth, or redness in one or both legs;
  • fever, chills, body aches, flu symptoms, sores in your mouth and throat;
  • pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • severe or ongoing vomiting or diarrhea;
  • bloody, black, or tarry stools;
  • coughing up blood or vomit that looks like coffee grounds;
  • feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin; or
  • high blood sugar (increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision).

Less serious side effects may include:

  • nausea, constipation, diarrhea;
  • loss of appetite, weight loss;
  • headache, tired feeling;
  • itching, chills;
  • dry mouth;
  • hair loss;
  • altered sense of taste;
  • muscle spasms; or
  • cold symptoms such as stuffy nose, sneezing, cough, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect vorinostat?

Tell your doctor about all other medicines you use, especially:

  • a blood thinner such as warfarin (Coumadin, Jantoven); or
  • valproic acid (Depakene, Stavzor).

This list is not complete and other drugs may interact with vorinostat. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about vorinostat.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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