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acetaminophen, chlorpheniramine, and dextromethorphan

Pronunciation: a SEET a MIN oh fen, klor fen IR a meen, dex troe meth OR fan

Brand: Coricidin HBP Maximum Strength Flu, Mapap Cough & Sinus Formula, Triaminic Flu Cough & Fever, Triaminic Multi-Symptom Fever, Tylenol Childrens Plus Cough & Runny Nose

What is the most important information I should know about this medicine?

Ask a doctor before taking medicine that contains acetaminophen if you have ever had liver disease, or if you drink more than 3 alcoholic beverages per day.

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Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death.

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Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP.

Multum noalcohol

Avoid drinking alcohol. It may increase your risk of liver damage while taking acetaminophen.

What is acetaminophen, chlorpheniramine, and dextromethorphan?

Acetaminophen is a pain reliever and fever reducer.

Chlorpheniramine is an antihistamine that reduces the effects of the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Dextromethorphan is a cough suppressant. It affects the cough reflex in the brain that triggers coughing.

Acetaminophen, chlorpheniramine, and dextromethorphan is a combination medicine used to treat headache, fever, body aches, cough, runny nose, sneezing, itching, and watery eyes caused by allergies, the common cold, or the flu.

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This medicine will not treat a cough that is caused by smoking, asthma, or emphysema.

Acetaminophen, chlorpheniramine, and dextromethorphan may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking this medicine?

Ask a doctor before taking medicine that contains acetaminophen if you have ever had liver disease, or if you drink more than 3 alcoholic beverages per day.

Do not use this medicine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include furazolidone, isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

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You should not use this medication if you are allergic to acetaminophen (Tylenol), chlorpheniramine, or dextromethorphan, or if you have:

  • severe constipation, blockage in your stomach or intestines;
  • untreated or uncontrolled diseases--glaucoma, asthma, high blood pressure, heart disease, coronary artery disease, overactive thyroid; or
  • if you are unable to urinate.

Ask a doctor or pharmacist before taking this medicine if you have any medical condition, especially:

  • kidney disease;
  • cough with mucus, or cough caused by emphysema or chronic bronchitis;
  • an enlarged prostate, problems with urination;
  • a history of alcoholism; or
  • if you take potassium (Cytra, Epiklor, K-Lyte, K-Phos, Kaon, Klor-Con, Polycitra, Urocit-K).
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It is not known whether this medicine will harm an unborn baby. Do not use cough and cold medicine without a doctor's advice if you are pregnant.

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This medicine may pass into breast milk and may harm a nursing baby. Antihistamines may also slow breast milk production. Do not use cough and cold medicine without a doctor's advice if you are breast-feeding a baby.

Artificially sweetened liquid medicine may contain phenylalanine. Check the medication label if you have phenylketonuria (PKU).

Multum nochild

Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

How should I take this medicine?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use for longer than recommended. Cough and cold medicine is usually taken only for a short time until your symptoms clear up.

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Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death.

Measure liquid medicine with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

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Stop taking the medicine and call your doctor if you still have a fever after 3 days, or you still have pain after 10 days (or 5 days if treating a child). Also call your doctor if your symptoms get worse, or if you have any redness or swelling.

If you need surgery or medical tests, tell the surgeon or doctor ahead of time if you have taken this medicine within the past few days.

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Store at room temperature away from moisture and heat. Do not allow liquid medicine to freeze.

What happens if I miss a dose?

Since this medicine is used when needed, you may not be on a dosing schedule. If you are on a schedule, use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

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Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of acetaminophen can be fatal.

The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness. Later symptoms may include pain in your upper stomach, dark urine, and yellowing of your skin or the whites of your eyes.

What should I avoid while taking this medicine?

Multum donot

Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP.

Multum noalcohol

Avoid drinking alcohol. It may increase your risk of liver damage while you are taking acetaminophen, and can increase certain side effects of chlorpheniramine.

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This medication may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

What are the possible side effects of this medicine?

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Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

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Stop using the medicine and call your doctor at once if you have:

  • severe headache, seizure (convulsions);
  • fast, pounding, or uneven heartbeats;
  • confusion, hallucinations, severe dizziness or drowsiness, slow or shallow breathing;
  • tremor, restless muscle movements;
  • little or no urinating;
  • flu symptoms, easy bruising, unusual bleeding, pale skin, weakness, feeling light-headed; or
  • nausea, pain in your upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects may include:

  • headache, sleep problems (insomnia);
  • upset stomach, diarrhea or constipation;
  • dry eyes, blurred vision, dry mouth or nose;
  • mild dizziness or drowsiness, trouble concentrating;
  • feeling restless or excited (especially in children); or
  • mild skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect this medicine?

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Taking this medicine with other drugs that make you sleepy or slow your breathing can increase these effects. Ask your doctor before taking a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

Ask a doctor or pharmacist if it is safe for you to use acetaminophen, chlorpheniramine, and dextromethorphan if you are also using any of the following drugs:

  • acetaminophen (Tylenol);
  • leflunomide, teriflunomide;
  • methotrexate;
  • tapentadol;
  • topiramate;
  • zonisamide;
  • an antibiotic, antifungal medicine, sulfa drug, or tuberculosis medicine;
  • an antidepressant;
  • birth control pills or hormone replacement therapy;
  • bladder or urinary medicines such as darifenacin, fesoterodine, oxybutynin, tolterodine, solifenacin;
  • bronchodilators such as ipratropium or tiotropium;
  • cholesterol-lowering medications--Crestor, Lipitor, Pravachol, Simcor, Vytorin, Zocor, and others;
  • gout or arthritis medications (including gold injections);
  • heart or blood pressure medication;
  • HIV or AIDS medications;
  • medication for Parkinson's disease;
  • medication to treat excess stomach acid, stomach ulcer, motion sickness, or irritable bowel syndrome;
  • medicines to treat mental illness;
  • an NSAID (non-steroidal anti-inflammatory drug)--ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), diclofenac, indomethacin, meloxicam, others;
  • seizure medication--carbamazepine, phenytoin, and others; or
  • steroids (prednisone and others).

This list is not complete. Other drugs may interact with acetaminophen, chlorpheniramine, and dextromethorphan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

Your pharmacist can provide more information about acetaminophen, chlorpheniramine, and dextromethorphan.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2013 Cerner Multum, Inc. Version: 2.02. Revision date: 2/10/2013.

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