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oxaliplatin

Pronunciation: ox AL i PLA tin

Brand: Eloxatin

Eloxatin 200 mg

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What is the most important information I should know about oxaliplatin?

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You should not receive this medication if you have ever had an allergic reaction to oxaliplatin or similar medications such as carboplatin (Paraplatin) or cisplatin (Platinol).

Before receiving oxaliplatin, tell your doctor if you are allergic to any drugs, or if you have liver or kidney disease, high blood pressure, a nerve problem, asthma, or if you are using a blood thinner.

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Receiving oxaliplatin can make you more sensitive to cold, which can cause numbness, tingling, and muscle spasms. This includes exposure to cold temperature and coming into contact with cold objects. To prevent discomfort avoid breathing in cold air, cover your skin in cold weather, wear gloves when handling cold objects, avoid air conditioning, and do not use ice or drink cold beverages.

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Oxaliplatin can lower blood cells that help your body fight infections and help your blood to clot. Your blood may need to be tested often. Avoid being near people who are sick or have infections. Avoid activities that may increase your risk of bleeding injury. Tell your doctor at once if you develop signs of infection.

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Call your doctor at once if you have a serious side effect such as confusion, change in mental status, vision loss, numbness or tingling, burning pain, jaw or chest tightness, eye pain, problems with speech or swallowing, trouble breathing, chest discomfort, cough, pain or burning when you urinate, rapid weight loss, flu symptoms, fever, chills, nausea and vomiting, mouth and throat ulcers, rapid and shallow breathing, easy bruising or bleeding, pale skin, feeling light-headed, rapid heart rate, feeling very thirsty or hot, or being unable to urinate.

What is oxaliplatin?

Oxaliplatin is a cancer medication that interferes with the growth and spread of cancer cells in the body.

Oxaliplatin is used together with other cancer medications to treat colon and rectal cancer.

Oxaliplatin may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before receiving oxaliplatin?

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You should not receive this medication if you have ever had an allergic reaction to oxaliplatin or similar medications such as carboplatin (Paraplatin) or cisplatin (Platinol).

To make sure you can safely receive oxaliplatin, tell your doctor if you have any of these other conditions:

  • kidney disease;
  • liver disease;
  • high blood pressure;
  • asthma or other breathing disorder;
  • a nerve problem; or
  • if you are using a blood thinner such as warfarin (Coumadin, Jantoven).
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FDA pregnancy category D. Do not use oxaliplatin if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

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It is not known whether oxaliplatin passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using oxaliplatin.

How is oxaliplatin given?

Oxaliplatin is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting.

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Receiving oxaliplatin can make you more sensitive to cold, which can cause numbness, tingling, and muscle spasms. This includes exposure to cold temperature and coming into contact with cold objects. To prevent discomfort, follow these steps:

  • do not inhale deeply when you are exposed to cold air;
  • cover your skin, head, and face when you are outside in cold temperatures;
  • wear gloves when handling cold objects or refrigerated foods;
  • do not run an air conditioner at very cool temperature in your home or car (even during hot weather);
  • do not drink cold drinks or use ice cubes in drinks;
  • do not put ice packs on your body.

Chemotherapy often causes nausea or mouth sores. Do not eat ice chips to ease these discomforts because you will be more sensitive to cold. Talk to your doctor about other ways to treat nausea or mouth sores. You may be given other medications to prevent nausea or vomiting while you are receiving oxaliplatin.

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You may need frequent medical tests at your doctor's office to be sure this medication is not causing harmful effects. Your cancer treatments may be delayed based on the results of these tests.

What happens if I miss a dose?

Contact your doctor if you miss an appointment for your oxaliplatin injection.

What happens if I overdose?

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Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe forms of some of the side effects listed in this medication guide.

What should I avoid while receiving oxaliplatin?

Avoid cold temperatures and cold objects, including ice, cold drinks, and skin exposure to cold temperatures.

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

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This medication may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

What are the possible side effects of oxaliplatin?

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Some people receiving a oxaliplatin injection have had a reaction to the infusion within minutes after the medicine is injected into the vein. Tell your caregiver right away if you feel dizzy, short of breath, confused, sweaty, itchy, or have diarrhea, chest pain, warmth or redness in your face, or feel like you might pass out.

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Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

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Call your doctor at once if you have a serious side effect such as:

  • headache, confusion, change in mental status, vision problems, seizure (convulsions);
  • numbness, tingling, or burning pain that interferes with daily activities;
  • increased sensitivity to cold temperatures and cold objects;
  • jaw or chest tightness, eye pain, strange feeling in your tongue, problems with speech or swallowing;
  • fever, chills, sore throat, mouth and throat ulcers, cough with mucus;
  • dry cough, wheezing, feeling short of breath on exertion;
  • pain or burning when you urinate;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • pale skin, feeling weak or tired, rapid heart rate, trouble concentrating;
  • pain, redness, swelling, or skin changes where the injection was given; or
  • feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin.

Other common side effects may include:

  • nausea, vomiting, stomach pain, loss of appetite;
  • diarrhea, constipation;
  • weight gain;
  • muscle pain; or
  • temporary hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect oxaliplatin?

Tell your doctor about all medications you use, and those you start or stop using during your treatment with oxaliplatin. Other drugs may interact with oxaliplatin, including prescription, over-the-counter, vitamin, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

Your doctor or pharmacist can provide more information about oxaliplatin.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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