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hydrochlorothiazide and bisoprolol

Pronunciation: HYE droe klor oh THYE a zide and bi SOE proe lol

Brand: Ziac

Bisoprolol-HCT 10 mg-6.25 mg-PUR

oblong, white, imprinted with 652, R

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Bisoprolol-HCT 10 mg-6.25 mg-WAT

round, white, imprinted with 843, WATSON

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Bisoprolol-HCT 2.5 mg-6.25 mg-WAT

round, yellow, imprinted with 841, WATSON

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Bisoprolol-HCT 5 mg-6.25 mg-WAT

round, pink, imprinted with 842, WATSON

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Bisoprolol-HCTZ 10 mg-6.25 mg-EON

round, white, imprinted with E 707

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Bisoprolol-HCTZ 10-6.25 mg-MYL

round, white, imprinted with 505, M

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Bisoprolol-HCTZ 2.5 mg-6.25 mg-EON

round, peach, imprinted with E 701

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Bisoprolol-HCTZ 2.5-6.25 mg-MYL

round, orange, imprinted with 501, M

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Bisoprolol-HCTZ 5 mg-6.25 mg-EON

round, red, imprinted with E 704

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Bisoprolol-HCTZ 5-6.25 mg-MYL

round, blue, imprinted with 503, M

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Ziac 10 mg

round, white, imprinted with LL, B 14

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Ziac 10 mg-BAR

round, white, imprinted with b, 40

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Ziac 2.5 mg

round, yellow, imprinted with LL, B 12

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Ziac 2.5 mg-BAR

round, yellow, imprinted with b, 47

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Ziac 5 mg

round, pink, imprinted with LL, B 13

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Ziac 5 mg-BAR

round, pink, imprinted with b, 50

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What is the most important information I should know about hydrochlorothiazide and bisoprolol?

Multum donot

You should not use this medication if you have severe or uncontrolled heart failure, a heart condition called "sick sinus syndrome" or "AV block," slow heartbeats, an allergy to sulfa drugs, or if you are unable to urinate.

Before using this medication, tell your doctor if you have congestive heart failure, circulation problems, kidney or liver disease, cirrhosis, glaucoma, asthma, bronchospastic lung disease, a thyroid disorder, lupus, gout, diabetes, or a penicillin allergy.

If you are diabetic, check your blood sugar carefully. Using bisoprolol can make it harder for you to tell when you have low blood sugar. Your insulin or diabetic medication needs may change while you are taking hydrochlorothiazide and bisoprolol. Talk with your doctor before changing any doses.

Multum noalcohol

Drinking alcohol can further lower your blood pressure and may increase certain side effects of hydrochlorothiazide and bisoprolol.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Multum finish

Keep using this medication even if you feel fine. High blood pressure often has no symptoms.

There are many other medicines that can interact with hydrochlorothiazide and bisoprolol. Tell your doctor about all the prescription and over-the-counter medications you use.

What is hydrochlorothiazide and bisoprolol?

Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Bisoprolol is a beta-blocker. Beta-blockers affect the heart and circulation (blood flow through arteries and veins).

The combination of hydrochlorothiazide and bisoprolol is used to treat high blood pressure (hypertension).

Hydrochlorothiazide and bisoprolol may also be used for purposes not listed in this medication guide.

What should I discuss with my doctor before taking hydrochlorothiazide and bisoprolol?

Multum donot

You should not use this medication if you are allergic to hydrochlorothiazide or bisoprolol, or if you have:

  • severe or uncontrolled heart failure;
  • a heart condition called "sick sinus syndrome" or "AV block" (2nd or 3rd degree);
  • slow heartbeats;
  • if you are unable to urinate;
  • if you are allergic to sulfa drugs; or
  • if you are allergic to any beta-blocker medication, such as atenolol (Tenormin), bisoprolol (Zebeta), labetalol (Normodyne, Trandate), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), timolol (Blocadren), and others.

To make sure you can safely take hydrochlorothiazide and bisoprolol, tell your doctor if you have any of these other conditions:

  • congestive heart failure;
  • blood circulation problems;
  • kidney disease;
  • liver disease (or cirrhosis);
  • glaucoma;
  • asthma, or bronchospastic lung disease;
  • a thyroid disorder;
  • lupus;
  • gout;
  • diabetes; or
  • a penicillin allergy.
Multum nopreg

FDA pregnancy category C. It is not known whether hydrochlorothiazide and bisoprolol will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

Multum nobrfeed

Hydrochlorothiazide can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using hydrochlorothiazide and bisoprolol.

How should I take hydrochlorothiazide and bisoprolol?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Multum food

Take the medicine with a meal or right after you eat.

Your doctor may occasionally change your dose to make sure you get the best results.

Multum donot

Do not stop using hydrochlorothiazide and bisoprolol suddenly, or you could have a serious or life-threatening heart problem. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication.

Your blood pressure will need to be checked often. Your blood and urine may both be tested if you have been vomiting or are dehydrated. Visit your doctor regularly.

If you are diabetic, check your blood sugar carefully. Using bisoprolol can make it harder for you to tell when you have low blood sugar. Your insulin or diabetic medication needs may change while you are taking hydrochlorothiazide and bisoprolol. Talk with your doctor before changing any doses.

Multum emt

If you need surgery or medical tests, tell the doctor ahead of time that you are taking medication that contains hydrochlorothiazide. You may need to stop using the medicine for a short time.

Multum finish

Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

Multum rt

Store in a tightly closed container at room temperature, away from heat, moisture, and light.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include fast or slow heart rate, confusion, weakness, shallow breathing, swelling, increased urination, and feeling like you might pass out.

What should I avoid while taking hydrochlorothiazide and bisoprolol?

Multum noalcohol

Drinking alcohol can further lower your blood pressure and may increase certain side effects of hydrochlorothiazide and bisoprolol.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Multum dizzy

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

What are the possible side effects of hydrochlorothiazide and bisoprolol?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Multum donot

Stop using this medication and call your doctor at once if you have any of these serious side effects:

  • eye pain, vision problems;
  • swelling, rapid weight gain, feeling short of breath, even with mild exertion;
  • fast, slow, or uneven heartbeat;
  • easy bruising or bleeding;
  • sudden numbness or weakness, especially on one side of the body;
  • sudden severe headache, confusion, problems with speech or balance;
  • chest pain, sudden cough, wheezing, rapid breathing, coughing up blood;
  • pain, swelling, warmth, or redness in one or both legs;
  • numbness or tingly feeling in your hands or feet;
  • feeling weak, drowsy, restless, or light-headed;
  • dry mouth, extreme thirst, confusion, increased urination, leg discomfort, muscle weakness or limp feeling, nausea and vomiting;
  • urinating less than usual or not at all;
  • fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or
  • upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

  • diarrhea, constipation, upset stomach;
  • dizziness, spinning sensation;
  • cough, runny nose;
  • ringing in your ears; or
  • blurred vision.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect hydrochlorothiazide and bisoprolol?

Multum dizzy

Tell your doctor if you regularly use any other medicines that make you light-headed (especially narcotic pain medication or barbiturates). They can add to the side effects of hydrochlorothiazide and bisoprolol.

Many drugs can interact with hydrochlorothiazide and bisoprolol. Below is just a partial list. Tell your doctor if you are using:

  • insulin or oral diabetes medication;
  • colestipol (Colestid) or cholestyramine (Prevalite, Questran);
  • steroids (prednisone and others);
  • lithium (Lithobid);
  • rifampin (Rifadin, Rifamate, Rimactane);
  • NSAIDs (non-steroidal anti-inflammatory drugs) such as aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others;
  • other heart or blood pressure medications such as clonidine (Catapres) or reserpine; or
  • a calcium channel blocker such as amlodipine (Norvasc, Caduet, Exforge, Lotrel, Tekamlo, Tribenzor, Twynsta, Amturnide), diltiazem (Cartia, Cardizem), nifedipine (Nifedical, Procardia), or verapamil (Calan, Covera, Isoptin, Verelan).

This list is not complete and other drugs may interact with hydrochlorothiazide and bisoprolol. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about hydrochlorothiazide and bisoprolol.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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