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estramustine

Pronunciation: ES tra MUS teen

Brand: Emcyt

What is the most important information I should know about estramustine?

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You should not use this medication if you are allergic to estramustine, or if you have a blood clot, swelling of a vein caused by a blood clot, or if you have ever had an allergic reaction to estradiol or nitrogen mustard.

Before taking estramustine, tell your doctor if you have a history of stroke or heart attack, diabetes, heart disease, high blood pressure, migraine headaches, seizures, liver or kidney disease, or Paget's disease.

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Take estramustine on an empty stomach, at least 1 hour before or 2 hours after a meal.

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Do not take this medication with milk, milk products, or calcium-rich foods such as ice cream, yogurt, broccoli, and others. Also avoid using antacids or vitamin/mineral supplements that contain calcium. Calcium can make it harder for your body to absorb estramustine, which could make it less effective.

If a man fathers a child while taking estramustine, the baby may have birth defects. Use a condom to prevent pregnancy during your treatment. Ask your doctor how long you should continue using condoms after you stop taking estramustine.

What is estramustine?

Estramustine is a cancer medication that interferes with the growth of cancer cells and slows their growth and spread in the body.

Estramustine is used to treat metastatic or progressive prostate cancer.

Estramustine may also be used for other purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking estramustine?

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You should not use this medication if you are allergic to estramustine, or if you have:

  • a blood clot;
  • swelling of a vein caused by a blood clot; or
  • if you have ever had an allergic reaction to estradiol or nitrogen mustard.

If you have any of these other conditions, you may need a dose adjustment or special tests to safely take estramustine:

  • a history of blood clot, stroke, or heart attack;
  • diabetes;
  • high blood pressure (hypertension);
  • heart disease or coronary artery disease (atherosclerosis);
  • congestive heart failure;
  • migraine headaches;
  • epilepsy or other seizure disorder;
  • liver disease;
  • kidney disease; or
  • a metabolic bone disease (such as Paget's disease).

If a man fathers a child while taking estramustine, the baby may have birth defects. Use a condom to prevent pregnancy during your treatment. Ask your doctor how long you should continue using condoms after you stop taking estramustine.

How should I take estramustine?

Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

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Take estramustine on an empty stomach, at least 1 hour before or 2 hours after a meal.

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Take this medication with water, not with milk or other dairy products.

To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your blood pressure may also need to be checked. Do not miss any scheduled appointments.

This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using estramustine.

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Store estramustine capsules in the refrigerator and do not allow it to freeze.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

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Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include swelling, shortness of breath, chest pain, or sudden numbness in any part of your body.

What should I avoid while taking estramustine?

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Do not take this medication with milk, milk products, or calcium-rich foods such as ice cream, yogurt, broccoli, and others. Also avoid using antacids or vitamin/mineral supplements that contain calcium. Calcium can make it harder for your body to absorb estramustine, which could make it less effective.

What are the possible side effects of estramustine?

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Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

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Stop using estramustine and call your doctor at once if you have a serious side effect such as:

  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
  • sudden numbness or weakness, especially on one side of the body;
  • sudden headache, confusion, problems with vision, speech, or balance;
  • chest pain, sudden cough, wheezing, rapid breathing, fast heart rate;
  • pain or swelling in one or both legs;
  • feeling short of breath, even with mild exertion;
  • swelling, rapid weight gain; or
  • easy bruising.

Less serious side effects may include:

  • nausea, loss of appetite, diarrhea, upset stomach;
  • feeling weak or tired;
  • breast swelling or tenderness; or
  • impotence.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect estramustine?

There may be other drugs that can interact with estramustine. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Where can I get more information?

Your doctor or pharmacist can provide more information about estramustine.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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