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midazolam (oral)

Pronunciation: mye DAZ oh lam

Brand: Versed

What is the most important information I should know about midazolam?

Multum donot

You should not take this medication if you have narrow-angle glaucoma, or if you are allergic to midazolam or to other benzodiazepines, such as alprazolam (Xanax), chlordiazepoxide (Librium), clorazepate (Tranxene), diazepam (Valium), lorazepam (Ativan), or oxazepam (Serax).

Multum nopreg

Do not use midazolam if you are pregnant. It could harm the unborn baby.

Before taking midazolam, tell your doctor if you have any breathing problems, glaucoma, kidney or liver disease, or a history of depression, suicidal thoughts, or addiction to drugs or alcohol.

Multum noalcohol

Do not drink alcohol shortly after taking midazolam. This medication can increase the effects of alcohol, which could be dangerous.

What is midazolam?

Midazolam is a benzodiazepine (ben-zoe-dye-AZE-eh-peen) sedative.

Midazolam is used to sedate a person who is having a minor surgery, dental work, or other medical procedure.

Midazolam may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking midazolam?

Multum donot

You should not take this medication if you have narrow-angle glaucoma, or if you are allergic to midazolam or to other benzodiazepines, such as alprazolam (Xanax), chlordiazepoxide (Librium), clorazepate (Tranxene), diazepam (Valium), lorazepam (Ativan), or oxazepam (Serax).

To make sure midazolam is safe for you, tell your doctor if you have any of these other conditions:

  • glaucoma;
  • asthma, emphysema, bronchitis, chronic obstructive pulmonary disorder (COPD), or other breathing problems;
  • kidney or liver disease;
  • congestive heart failure;
  • a history of depression or suicidal thoughts or behavior; or
  • a history of drug or alcohol addiction.
Multum nopreg

FDA pregnancy category D. Do not use midazolam if you are pregnant. It could harm the unborn baby. Before you receive this medication, tell your doctor if you are pregnant.

Multum nobrfeed

Midazolam can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

The sedative effects of midazolam may last longer in older adults. Accidental falls are common in elderly patients who take benzodiazepines. Use caution to avoid falling or accidental injury while you are taking midazolam.

How should I take midazolam?

Midazolam is usually given as a single dose just before your surgery or procedure. You will receive this medicine in a hospital or clinic setting to quickly treat any serious side effects that occur.

You will be watched closely after receiving midazolam, to make sure you do not have an allergic reaction or serious side effects.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of midazolam can be fatal.

Overdose symptoms may include severe forms of some of the side effects listed in this medication guide.

What should I avoid while taking midazolam?

Multum noalcohol

Do not drink alcohol shortly after taking midazolam. This medication can increase the effects of alcohol, which could be dangerous.

Grapefruit and grapefruit juice may interact with midazolam and lead to potentially dangerous effects. Avoid the use of grapefruit products while taking midazolam.

Multum dizzy

This medication may impair your thinking or reactions. Avoid driving or operating machinery until you know how midazolam will affect you.

What are the possible side effects of midazolam?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Multum donot

Call your doctor at once if you have a serious side effect such as:

  • cough, wheezing, trouble breathing, weak or shallow breathing;
  • slow heart rate;
  • seizure (convulsions);
  • feeling like you might pass out;
  • agitation, hostility; or
  • confusion, hallucinations, unusual thoughts or behavior.

Less serious side effects may include:

  • drowsiness, dizziness;
  • blurred vision;
  • nausea, vomiting;
  • runny nose, sneezing;
  • mild rash; or
  • amnesia or forgetfulness after your procedure.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect midazolam?

Multum dizzy

Before using midazolam, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, other sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by midazolam.

Tell your doctor about all other medicines you use, especially:

  • boceprevir (Victrelis);
  • bosentan (Tracleer);
  • cimetidine (Tagamet);
  • conivaptan (Vaprisol);
  • dexamethasone (Cortastat, Dexasone, Solurex, DexPak);
  • imatinib (Gleevec);
  • isoniazid (for treating tuberculosis);
  • nefazodone;
  • St. John's wort;
  • an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), rifampin (Rifadin, Rifater, Rifamate), or telithromycin (Ketek);
  • antifungal medication such as fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), miconazole (Oravig), posaconazole (Noxafil), or voriconazole (Vfend);
  • a barbiturate such as butabarbital (Butisol), secobarbital (Seconal), pentobarbital (Nembutal), or phenobarbital (Solfoton);
  • heart or blood pressure medication such as diltiazem (Cardizem, Cartia, Dilacor, Diltia, Diltzac, Taztia, Tiazac), nicardipine (Cardene), quinidine (Quin-G), or verapamil (Calan, Covera, Isoptin, Verelan, Tarka);
  • HIV/AIDS medication such as atazanavir (Reyataz), delavirdine (Rescriptor), efavirenz (Sustiva, Atripla), etravirine (Intelence), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, Kaletra), saquinavir (Invirase), or telaprevir (Incivek); or
  • seizure medication such as carbamazepine (Carbatrol, Equetro, Tegretol), felbamate (Felbatol), oxcarbazepine (Trileptal), phenytoin (Dilantin), or primidone (Mysoline).

This list is not complete and other drugs may interact with midazolam. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about midazolam.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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