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Juvenile Myelomonocytic Leukemia (JMML)

About Leukemia

Leukemia is a type of cancer that affects the body's white blood cells (WBCs).

Normally, WBCs help fight infection and protect the body against disease. But in leukemia, WBCs turn cancerous and multiply when they shouldn't, resulting in too many abnormal WBCs, which then interfere with organ function.

If too many myelocytes and monocytes (certain types of immature WBCs) are produced, a child has juvenile myelomonocytic leukemia (JMML). This type of leukemia mostly affects kids younger than 2 years old.

Causes

The cause of JMML is unknown, but doctors do know that certain medical conditions — such as neurofibromatosis type 1 and Noonan's syndrome — can make a child more likely to develop it.

Signs and Symptoms

JMML tends to progress slowly, so at first a child may have few if any symptoms. In fact, symptoms can take months or even years to develop.

The symptoms of all types of leukemia are generally the same and include:

  • fatigue and weakness
  • swollen lymph nodes
  • recurrent infections (like bronchitis or tonsillitis)
  • fever
  • easy bruising
  • bone and joint pain
  • abdominal pain (caused by abnormal blood cells accumulating in organs like the kidneys, liver, and spleen)

Diagnosis

A doctor who suspects a child has leukemia may order tests that include:

  • Blood tests. Tests such as a complete blood count, liver and kidney function panels, and blood chemistries can give important information about the number of normal blood cells in the body and how well the organs are functioning. The blood cells will also be examined under a microscope to check for abnormal shapes or sizes.
  • Bone marrow aspiration. In this procedure, the doctor inserts a needle into a large bone, usually the hip, and removes a small amount of bone marrow to examine it for abnormal cells.
  • Imaging studies. These may include an X-ray, CT scan, MRI, or ultrasound to check for an enlarged spleen or liver, and also to rule out any other possible causes of a child's symptoms.

Treatment

Chemotherapy (the use of drugs to kill cancer cells) may be used to temporarily control JMML. However, effective treatment of JMML usually involves a stem cell transplant, also called a bone marrow transplant.

This procedure involves destroying cancer cells and normal bone marrow and immune system cells with high-dose chemotherapy and then re-introducing healthy donor stem cells into the body. The new stem cells can rebuild a healthy blood supply and immune system.

If a child needs a stem cell transplant, a test (called tissue typing or HLA [human leukocyte antigen] typing) will be done to help doctors find a suitable stem cell donor. This works by comparing the proteins on the surface of a child's blood cells with the proteins on a potential donor's cells. The more "HLA markers" a child and donor share, the greater the chance that the transplant will be successful.

Even though these therapies are the treatment of choice for kids with JMML, the disease remains difficult to cure. As a result, researchers are looking into whether immunotherapy (the use of immune-boosting drugs to help the body fight disease) also may be an effective treatment.

Coping

Being told that your child has cancer can be a terrifying experience, and the stress of treating the disease can be overwhelming for any family.

Although you might feel like it at times, you're not alone. To find out about support that may be available to you or your child, talk to your doctor or a hospital social worker. Many resources are available that can help you get through this difficult time.

Reviewed by: Christopher N. Frantz, MD
Date reviewed: June 2009

Kids Health

Note: All information is for educational purposes only. For specific medical advice, diagnoses, and treatment, consult your doctor.

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