John Lee, MD

location phone (605) 328-8200
John Lee, MD - Ear, Nose & Throat



Accepting New Patients


Undergraduate School
Stanford University (Palo Alto, CA)
Medical School
University of Minnesota (Minneapolis, MN)
University of Iowa (Iowa City, IA)
American Board of Otolaryngology

Areas of Expertise

  • Thyroid/Parathyroid Tumors
  • Parotid Tumors
  • Throat Tumors
  • Balloon Sinuplasty
  • Endoscopic Removal of Pituitary and Skull Base Tumors
  • Head and neck surgery
  • Unique Medical Experience and Research

    Dr. Lee, who was honored in 2010 by the American Cancer Society for his research, has been studying the link between the Human Papilloma Virus (HPV) and the development of head and neck cancers. He is conducting a clinical trial to test the safety and effectiveness of a drug treatment on patients receiving radiation and chemotherapy for head and neck cancer. The trial will evaluate how a medication that can alter cell metabolism can affect the outcome for cancer patients. For more information on this clinical trial, click here.

    Dr. Lee received his formal undergraduate education at Stanford University and then went on to be clinically trained at the University of Iowa ENT residency program, which was ranked number 2 in the U.S. for 10 years. Dr. Lee was also a professor at the University of Iowa where he published over 20 articles and book chapters. He is experienced in sub-specialized surgical care for head and neck cancer patients and is a National Cancer Institute Cancer Center member. Click here to read Dr. Lee's most recent study, "Identical but Different: Mechanism of Cancer Development and Response to Treatment for Human Papillomavirus-Related and Non-Related Squamous Cell Cancer of the Head and Neck."

    Dr. Lee is a member of the American College of Surgeons (FACS) and the American Head and Neck Surgeons.

    Languages Spoken


    Hobbies and Personal Interests

    Dr. Lee enjoys hunting and basketball in his free time.


    Primary Practice Location

    Sanford Ear, Nose and Throat Clinic

    1310 W 22nd Street
    Sioux Falls, SD 57105
    Get Directions


    M–F: 8:00 AM–5:00 PM



    (605) 328-8200


    (605) 328-8201