Sanford Researcher Published in Top Cancer Research Journal

Sanford Researcher Published in Top Cancer Research Journal

Meena Jaggi, PhD

(Sioux Falls, SD) – Meena Jaggi, PhD, a cancer researcher with Sanford Research/USD, has accomplished the unprecedented achievement of being published not once, but twice in the same issue of Cancer Research, the #1 national cancer research journal released by the American Association for Cancer Research. The journal is read by more than 20,000 scientists and researchers around the globe, who will use that information to develop more effective cancer treatments.

Dr. Jaggi contributed to two articles in the February issue. One article focused on the discovery of a molecule, protein kinase D1 (PKD1), and how it interacts with beta-catenin. Due to an unusual expression of beta-catenin, cancer cells lose their cell-cell contacts and become more aggressive and metastatic. The article detailed how PKD1 molecule is involved in prostate cancer cells. See article.

In another article, Dr. Jaggi reported a novel molecular marker, MUC13, which is highly expressed in ovarian cancer. In addition to identification of this novel marker, for the first time, the functional roles of MUC13 in ovarian cancer were also reported. Both these discoveries are important because prostate cancer is the most-diagnosed cancer for men in the United States and ovarian cancer is cited as one of the most lethal gynecological malignancies. See article.

"To be published in a cancer research journal of this impact is a remarkable achievement in itself," said Ben Perryman, Sanford Vice President of Research. "To be published twice in the same speaks to the skill and dedication of Sanford/USD researchers in discovering new approaches for the development of treatments for cancer. Dr. Jaggi's discoveries will have a significant impact on this aspect of cancer research."