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Sources: Donald A. Henderson, MD, and the U.S. Centers for Disease Control and Prevention (CDC). Adapted with permission. All rights reserved.
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Chickenpox | Smallpox |
| How initial symptoms differ |
0 to 2 days of mild illness pass before the rash develops. |
2 to 3 days of severe illness pass before the rash develops. |
|---|---|---|
|
Lesions first appear on the face or trunk. |
Lesions first appear in the throat or mouth, then on the face, or on the upper arms. |
|
| How the rash lesions differ |
Lesions develop in successive fashion. While some are new, others are crusting over (in "crops"). |
Lesions develop at the same time, and they look alike on any one section of the body, such as the abdomen, arms, or face. |
|
Lesions change rapidly, crusting over within 24 hours. |
Lesions change slowly, scabbing over after 9 to 15 days. |
|
|
Lesions sit on the skin surface like a "dewdrop on a rose petal." |
Lesions become firm, dome-shaped, and deep in the skin. |
|
|
Rash rarely develops on palms and soles. |
Rash commonly develops on palms of the hands and soles of the feet. |
|
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Lesions are most concentrated on the torso, with fewest on the hands and feet. Lesions can affect the face and scalp, but rarely affect the entire body equally. |
Lesions are most concentrated on the face, hands, and feet. |
Last Revised: December 16, 2010
Author: Healthwise Staff
Medical Review: E. Gregory Thompson, MD - Internal Medicine & Christine Hahn, MD - Epidemiology
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