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This topic talks about the testing, diagnosis, and treatment of cervical cancer. For general information about abnormal Pap test results, see the topic Abnormal Pap Test.
Cervical cancer occurs when abnormal cells on the cervix grow out of control. The cervix is the lower part of the uterus that opens into the vagina. Cervical cancer can often be successfully treated when it's found early. It is usually found at a very early stage through a Pap test.
Cervical cancer is one of the most common cancers in women.
Most cervical cancer is caused by a virus called human papillomavirus, or HPV. You can get HPV by having sexual contact with someone who has it. There are many types of the HPV virus. Not all types of HPV cause cervical cancer. Some of them cause genital warts, but other types may not cause any symptoms.
You can have HPV for years and not know it. It stays in your body and can lead to cervical cancer years after you were infected. This is why it is important for you to have regular Pap tests. A Pap test can find changes in cervical cells before they turn into cancer. If you treat these cell changes, you may prevent cervical cancer.
Abnormal cervical cell changes rarely cause symptoms. But you may have symptoms if those cell changes grow into cervical cancer. Symptoms of cervical cancer may include:
As part of your regular pelvic exam, you should have a Pap test. During a Pap test, the doctor scrapes a small sample of cells from the surface of the cervix to look for cell changes. If a Pap test shows abnormal cell changes, your doctor may do other tests to look for precancerous or cancer cells on your cervix.
Your doctor may also do a Pap test and take a sample of tissue (biopsy) if you have symptoms of cervical cancer, such as bleeding after sex.
The treatment for most stages of cervical cancer includes:
Depending on how much the cancer has grown, you may have one or more treatments. And you may have a combination of treatments. If you have a hysterectomy, you won't be able to have children. But a hysterectomy isn't always needed, especially when cancer is found very early.
It's common to feel scared, sad, or angry after finding out that you have cervical cancer. Talking to others who have had the disease may help you feel better. Ask your doctor about support groups in your area. You can also find people online who will share their experiences with you.
The Pap test is the best way to find cervical cell changes that can lead to cervical cancer. Regular Pap tests almost always show these cell changes before they turn into cancer. It's important to follow up with your doctor after any abnormal Pap test result so you can treat abnormal cell changes. This may help prevent cervical cancer.
If you are age 26 or younger, you can get the HPV vaccine, which protects against two types of HPV that cause cervical cancer.
The virus that causes cervical cancer is spread through sexual contact. The best way to avoid getting a sexually transmitted infection is to not have sex. If you do have sex, practice safer sex, such as using condoms and limiting the number of sex partners you have.
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Cervical cancer is caused by severe abnormal changes in the cells of the cervix. Most precancerous or cancerous cell changes occur in the cervix at the transformation zone, because these cells normally undergo constant change. During this natural process of change, some cervical cells can become abnormal if you are infected with high-risk types of HPV.
Other factors may play a role in causing cervical cancer, such as having more than one sex partner or smoking cigarettes. For more information on risk, see What Increases Your Risk.
Abnormal cervical cell changes rarely cause symptoms. If cervical cell changes progress to cancer, symptoms may include:
The symptoms of advanced cervical cancer may include:
Cervical cancer happens when abnormal cells on the cervix grow out of control. Cervical cancer can often be successfully treated when it's found early. It is usually found at a very early stage through a Pap test.
If cervical cancer isn't treated, it may spread from the cervix to the vagina, and then into deeper tissue layers of connective tissue around the uterus. As it progresses, it may spread to the pelvic lymph nodes and other pelvic organs. Advanced-stage cancer may spread to lymph nodes; to other organs in the pelvis, causing problems with kidney and bowel function; or to other organs in the body, such as the liver and lungs.
Treatment of cervical cancer depends on the stage of your cancer and if it has spread. To learn more, see Treatment Overview.
Things that may increase your risk for cervical cancer include:
Call your doctor if you have:
If you are diagnosed
If you have been diagnosed with cervical cancer, be sure to follow your doctor's instructions about calling when you have problems, new symptoms, or symptoms that get worse.
Health professionals who can evaluate your symptoms and your risk factors, and who can diagnose cervical cancer include:
Doctors who can manage your cancer treatment include:
To prepare for your appointment, see the topic Making the Most of Your Appointment.
The Pap test is a routine screening test used to find abnormal cell changes of the cervix and to screen for cervical cancer. Regular Pap test screening is the most important tool in finding and treating cervical cell changes before they progress to cervical cancer.
The recommended Pap test schedule is based on your age and things that increase your risk. Talk to your doctor about how often to have this test.
If cervical cancer is suspected, your doctor will ask about your medical history and perform a physical exam, including a pelvic exam and a Pap test.
Tests to confirm a diagnosis of cervical cancer include:
Tests to find the extent (stage) of cervical cancer include:
A surgery or procedure may be done to find out the extent of cervical cancer and treat it at the same time. For more information, see Surgery.
Other tests may be done to help guide treatment decisions. For example, you may have:
Cervical cancer found in its early stages can be successfully treated. The choice of treatment and the long-term outcome (prognosis) of cervical cancer depend on the type and stage of cancer. Your age, overall health, quality of life, and desire to be able to have children must also be considered.
Treatment choices for cervical cancer may be a single therapy or a combination of therapies, such as:
For more information about specific cervical cancer treatments, see the topics:
Most treatments for cervical cancer cause side effects. Your doctor can talk to you about your treatment choices and the side effects from each treatment.
Home treatment may help relieve some common side effects of cancer treatment. For more information, see Home Treatment.
When you first find out that you have cancer, you may feel scared or angry. Or you may feel very calm. It's normal to have a wide range of feelings and for those feelings to change quickly. Some people find that it helps to talk about their feelings with family and friends.
If your emotional reactions to cancer get in the way of your ability to make decisions about your health, it's important to talk with your doctor. Your cancer treatment center may offer psychological or financial services. And a local chapter of the American Cancer Society can help you find a support group.
Your feelings about your body and your sexuality may change following treatment for cancer. Managing body image issues may involve talking openly with your partner about your feelings and discussing your concerns with your doctor. Your doctor may be able to refer you to organizations that can offer additional support and information.
Cancer treatment during pregnancy is the same as for nonpregnant women. But when you'll get treatment may depend on the stage of your cancer and what trimester you are in. For example, if you have early-stage cervical cancer and you are in your third trimester, your treatment may be delayed until after you deliver your baby. Treatment may cause problems such as an early delivery or even the loss of the baby.
After treatment for cervical cancer, it is important to receive follow-up care. Your oncologist or gynecologic oncologist will schedule regular checkups that will include:2
Follow-up tests that may be recommended by your oncologist include an abdominal and pelvic computed tomography (CT) scan. This test is to see if cancer has spread to other organs in the belly or pelvis.
Cervical cancer can return, or recur, after treatment. About 35 out of 100 women with cervical cancer will have persistent or recurrent disease.3 That means that the cancer doesn't come back in 65 out of 100 cases. The chance that your cancer will return depends on the stage of the initial cancer. Cancer found early is less likely to come back than cancer found at a later stage.
Your long-term outcome (prognosis) for recurrent cervical cancer depends greatly on how much the cancer has spread when the recurrence is diagnosed.
Cancer treatment has two main goals: curing cancer and making your quality of life as good as possible. Palliative care can improve your quality of life by helping you manage your symptoms. It can also help you with other concerns that you may have when you are living with a serious illness.
For some people who have advanced cancer, a time comes when treatment to cure cancer no longer seems like a good choice. This can be because the side effects, time, and costs of treatment are greater than the promise of cure or relief. But this isn't the end of treatment. You and your doctor can decide when you may be ready for hospice care.
It can be hard to decide when to stop treatment aimed at prolonging your life and shift the focus to end-of-life care. For more information, see the topics:
You can treat early cervical cell changes (dysplasia), which can reduce your risk for cervical cancer. You can also reduce your risk for abnormal cell changes.
The recommended Pap test schedule is based on your age and things that increase your risk. Talk to your doctor about how often to have this test.
Women who smoke cigarettes or who breathe in secondhand smoke have a higher risk for cervical cell changes that can lead to cervical cancer. Quitting smoking may decrease this risk.4
If you are a woman age 26 or younger or a man age 21 and younger, get the HPV vaccine. The vaccines Cervarix(What is a PDF document?) and Gardasil(What is a PDF document?) protect against two types of human papillomavirus (HPV) that cause cervical cancer. It is recommended for children age 11 or 12, but can be given as early as age 9. For girls who have not already gotten the vaccine, it is recommended up to age 26. For boys who have not already gotten the shot, the vaccine is recommended up to age 21. Gardasil is used for males. Females can get either vaccine. For more information, see the topic Immunizations.
Preventing an STI, including HPV, is easier than treating an infection after it occurs. HPV infection usually doesn't cause symptoms, so you or your partner may not know that you are infected.
To reduce your risk:
Not having sexual contact is the only certain way to prevent exposure to STIs. Sexually transmitted infections such as human papillomavirus (HPV) can be spread to or from the genitals, anus, mouth, or throat during sexual activities.
The side effects of cancer treatment can be serious. Healthy habits such as eating a balanced diet and getting enough sleep and exercise may help control your symptoms. Your doctor may also give you medicines to help you with certain side effects.
Other symptoms that can be treated at home include:
Chemotherapy is used to shrink cervical cancer and decrease tumor growth. It may be used alone or along with radiation (chemoradiation). Compared with radiation alone, chemoradiation improves survival.6 It is usually used as the main treatment or after a hysterectomy. Chemotherapy may also be used to treat cervical cancer that has spread beyond the cervix.
Common chemotherapy medicines used to treat cervical cancer include:
Most chemotherapy will cause some side effects, such as nausea, vomiting, and hair loss. Your doctor may also give you medicines to control and prevent nausea and vomiting. Home treatment may also help relieve other common side effects of cancer treatment. For more information, see Home Treatment.
Surgery to remove the cancer depends on the location and extent of cervical cancer and your desire to be able to have children. You also may be given radiation therapy, chemotherapy, or a combination of the two (chemoradiation). These treatments may be given before or after surgery to try to destroy any cancer cells that may remain or to help control or shrink the tumor.
Surgery for very early stages of cervical cancer may preserve your ability to have children. Surgeries include:
Surgery for most stages of cervical cancer does not preserve your ability to have children. Surgeries include:
Side effects from surgery can include difficulty with urination or problems with bowel habits, such as constipation or diarrhea. Your ability to have or enjoy sexual intercourse may also be affected.
Home treatment may help relieve some common side effects of cancer treatment. For more information, see Home Treatment.
Radiation therapy is used for certain stages of cervical cancer, often along with surgery. Chemotherapy may be given at the same time as radiation treatment (chemoradiation) to improve survival rates. Chemoradiation may be used as the main treatment or after a hysterectomy.
Radiation therapy uses high-energy X-rays to kill cancer cells and shrink tumors. Radiation may come from a machine outside the body (external radiation therapy). Or it may come from radiation material (radioisotopes) in thin plastic tubes inserted through the vagina into the cervical area where the cancer cells are found.
Radiation may cause many side effects, including diarrhea and irritation of the bladder (radiation cystitis). Home treatment may help relieve some common side effects of cancer treatment. For more information, see Home Treatment.
Your ability to have or enjoy sexual intercourse may also be affected. This is because radiation may cause changes to the cells lining the vagina (mucosa), making intercourse difficult or painful. A series of vaginal dilators, starting with a small one and progressing to a larger size, may be used after radiation therapy. Using the dilators can make the vaginal opening larger and help make sex less difficult or painful.
Radiation to treat cervical cancer may thin the bone and increase the risk of fractures in the pelvic area, including hip fractures. You can take steps to prevent thinning of the bone (osteoporosis), such as getting enough calcium and vitamin D. Also, try to prevent falls, which can lead to fractures. For more information, see the topic Osteoporosis.
Some women with cervical cancer may be interested in taking part in research studies called clinical trials. Clinical trials are designed to find better ways to treat cancer patients. They are based on the most up-to-date information. Women who don't want standard treatments or are not cured using standard treatments may want to take part in clinical trials. These are ongoing in most parts of the United States and in some other countries for all stages of cervical cancer.
People sometimes use complementary therapies along with medical treatment to help relieve symptoms and side effects of cancer treatments. Some of the therapies that may be helpful include:
These mind-body treatments may help you feel better. They can make it easier to cope with treatment. They also may reduce chronic low back pain, joint pain, headaches, and pain from treatments.
Before you try a complementary therapy, talk to your doctor about the possible value and potential side effects. Let your doctor know if you are already using any of these therapies. They are not meant to take the place of standard medical treatment.
| American Cancer Society (ACS) | |
| Phone: | 1-800-ACS-2345 (1-800-227-2345) |
| TDD: | 1-866-228-4327 toll-free |
| Web Address: | www.cancer.org |
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The American Cancer Society (ACS) conducts educational programs and offers many services to people with cancer and to their families. Staff at the toll-free numbers have information about services and activities in local areas and can provide referrals to local ACS divisions. |
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| American Congress of Obstetricians and Gynecologists (ACOG) | |
| 409 12th Street SW | |
| P.O. Box 96920 | |
| Washington, DC 20090-6920 | |
| Phone: | (202) 638-5577 |
| Email: | resources@acog.org |
| Web Address: | www.acog.org |
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American Congress of Obstetricians and Gynecologists (ACOG) is a nonprofit organization of professionals who provide health care for women, including teens. The ACOG Resource Center publishes manuals and patient education materials. The Web publications section of the site has patient education pamphlets on many women's health topics, including reproductive health, breast-feeding, violence, and quitting smoking. |
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| Centers for Disease Control and Prevention (CDC) | |
| 1600 Clifton Road | |
| Atlanta, GA 30333 | |
| Phone: | 1-800-CDC-INFO (1-800-232-4636) |
| TDD: | 1-888-232-6348 |
| Email: | cdcinfo@cdc.gov |
| Web Address: | www.cdc.gov |
|
The Centers for Disease Control and Prevention (CDC) is an agency of the U.S. Department of Health and Human Services. The CDC works with state and local health officials and the public to achieve better health for all people. The CDC creates the expertise, information, and tools that people and communities need to protect their health—by promoting health, preventing disease, injury, and disability, and being prepared for new health threats. |
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| National Cancer Institute (NCI) | |
| 6116 Executive Boulevard | |
| Suite 300 | |
| Bethesda, MD 20892-8322 | |
| Phone: | 1-800-4-CANCER (1-800-422-6237) |
| Web Address: | www.cancer.gov (or https://cissecure.nci.nih.gov/livehelp/welcome.asp# for live help online) |
|
The National Cancer Institute (NCI) is a U.S. government agency that provides up-to-date information about the prevention, detection, and treatment of cancer. NCI also offers supportive care to people who have cancer and to their families. NCI information is also available to doctors, nurses, and other health professionals. NCI provides the latest information about clinical trials. The Cancer Information Service, a service of NCI, has trained staff members available to answer questions and send free publications. Spanish-speaking staff members are also available. |
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| National Women's Health Information Center | |
| 8270 Willow Oaks Corporate Drive | |
| Fairfax, VA 22031 | |
| Phone: | 1-800-994-9662 (202) 690-7650 |
| Fax: | (202) 205-2631 |
| TDD: | 1-888-220-5446 |
| Web Address: | www.womenshealth.gov |
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The National Women's Health Information Center (NWHIC) is a service of the U.S. Department of Health and Human Services Office on Women's Health. NWHIC provides women's health information to a variety of audiences, including consumers, health professionals, and researchers. |
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| Women's Cancer Network | |
| 230 West Monroe | |
| Suite Suite 2528 | |
| Chicago, IL 60606 | |
| Phone: | 312-578-1439 |
| Email: | info@thegcf.org |
| Web Address: | www.wcn.org |
|
The Women's Cancer Network provides information about cancers of the female reproductive tract (ovary, endometrium, cervix, vulva, and vagina) for women and their families. Their goal is to help women understand more about the disease, learn about treatment options, and have access to new or experimental therapies. This Web site was developed by The Gynecologic Cancer Foundation, a non-profit organization with a mission to help people learn how to prevent, diagnose, and treat cancers of the female reproductive tract. |
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Citations
- Chirenje ZM (2005). HIV and cancer of the cervix. Best Practice and Research Clinical Obstetrics and Gynaecology, 19(2): 269–276.
- National Comprehensive Cancer Network (2010). Cervical Cancer, version 1. Available online: http://www.nccn.org/professionals/physician_gls/PDF/cervical.pdf.
- American College of Obstetricians and Gynecologists (2002, reaffirmed 2008). Diagnosis and treatment of cervical carcinomas. ACOG Practice Bulletin No. 35. Obstetrics and Gynecology, 99(5): 855–867.
- National Cancer Institute (2010). Cervical Cancer (PDQ): Prevention—Health Professional Version. Available online: http://www.nci.nih.gov/cancertopics/pdq/prevention/cervical/healthprofessional.
- Winer RL, et al. (2006). Condom use and the risk of genital human papillomavirus infection in young women. New England Journal of Medicine, 354(25): 2645–2654.
- Sundar S, et al. (2008). Cervical cancer, search date November 2006. Online version of BMJ Clinical Evidence. Also available online: http://www.clinicalevidence.com.
Other Works Consulted
- American Cancer Society (2009). Cancer Facts and Figures for African Americans 2009–2010. Atlanta: American Cancer Society. Available online: http://www.cancer.org/downloads/STT/cffaa_2009-2010.pdf.
- Balasubramanian A, et al. (2008). Cervical neoplasia and other STD-related genital tract neoplasias. In KK Holmes et al., eds., Sexually Transmitted Diseases, 4th ed., pp. 1051–1074. New York: McGraw-Hill.
- Eifel PJ, et al. (2008). Cancer of the cervix, vagina, and vulva. In VT DeVita Jr et al., eds., DeVita, Hellman, and Rosenberg’s Cancer: Principles and Practice of Oncology, 8th ed., vol. 2, pp. 1496–1543. Philadelphia: Lippincott Williams and Wilkins.
- National Cancer Institute (2010). Cervical Cancer PDQ: Treatment – Health Professional Version. Available online: http://www.cancer.gov/cancertopics/pdq/treatment/cervical/HealthProfessional.
- National Cancer Institute (2010). Cervical Cancer PDQ: Treatment – Patient Version. Available online: http://www.cancer.gov/cancertopics/pdq/treatment/cervical/patient.
- U.S. Preventive Services Task Force (2012). Screening for cervical cancer: Summary of recommendations. Available online: http://www.uspreventiveservicestaskforce.org/uspstf/uspscerv.htm.
| By | Healthwise Staff |
|---|---|
| Primary Medical Reviewer | Adam Husney, MD - Family Medicine |
| Specialist Medical Reviewer | Ross Berkowitz, MD - Obstetrics and Gynecology |
| Last Revised | May 4, 2012 |
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Medical Review: Adam Husney, MD - Family Medicine & Ross Berkowitz, MD - Obstetrics and Gynecology
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