Mononucleosis (mono) may cause an enlarged spleen. The enlarged spleen may rupture if you are hit in the abdomen or lift something heavy. A ruptured spleen is serious and requires immediate surgery to correct.
To reduce the risk of having a ruptured spleen, avoid heavy lifting or contact sports for 4 weeks after you become ill with mono or until your doctor says it is safe.
Last Revised: July 28, 2011
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