It is possible that the main title of the report WHIM Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
WHIM syndrome is a rare primary immunodeficiency disorder, which are disorders in which the body's immune system does not function properly. WHIM is an acronym for some of the characteristic symptoms of the disorder - (w)arts, (h)ypogammaglobulinemia, (i)nfections, and (m)yelokathexis. Individuals with WHIM syndrome are more susceptible to potentially life-threatening bacterial infections. To a lesser extent, they are also predisposed to viral infections. Affected individuals are particularly susceptible to human papillomavirus (HPV), which can cause skin and genital warts and potentially lead to cancer. Affected individuals have extremely low levels of certain white bloods (neutrophils) in the blood (neutropenia). In most cases, WHIM syndrome is caused by mutations of the CXCR4 gene. This mutation is inherited as an autosomal dominant trait.
WHIM syndrome is a primary immunodeficiency disorder, one of a group of disorders characterized by irregularities in the cell development and/or cell maturation process of the immune system. The immune system is divided into several components, the combined actions of which are responsible for defending against infectious agents. The T cell system (cell-mediated immune response) contributes to fighting several viruses, some bacteria and yeast and fungi. The B cell system (humoral immune response) fights infection caused by other viruses and bacteria. It does so by secreting immune factors called antibodies (also known as immunoglobulins) into the fluid portion of the blood (serum) and body secretions (e.g. saliva). There are five classes of immunoglobulins (Ig) known as IgA, IgD, IgE, IgG, and IgM. Antibodies can directly kill microorganisms or coat them so they are more easily destroyed by white blood cells.
Immune Deficiency Foundation
40 W. Chesapeake Avenue
Towson, MD 21204
NIH/National Institute of Allergy and Infectious Diseases
Office of Communications and Government Relations
6610 Rockledge Drive, MSC 6612
Bethesda, MD 20892-6612
International Patient Organization for Primary Immunodeficiencies
Firside Main Road
Cornwall, PL11 3LE
Jeffrey Modell Foundation
780 Third Avenue
New York, NY 10017
Canadian Immunodeficiencies Patient Organization
362 Concession Road 12 RR # 2
Hastings, Ontario, K0L 1Y0
Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
European Society for Immunodeficiencies
1-3 rue de Chantepoulet
Geneva, CH 1211
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It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report
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Last Updated: 7/3/2013
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