|Generic Name||Brand Name|
|interferon alfa-2b||Intron A|
|pegylated interferon alfa-2a (peginterferon)||Pegasys|
Interferon is a man-made copy of a protein that your body makes in response to infection. It helps the immune system fight disease and may slow or stop the growth of the hepatitis B virus in your body.
Interferon is given as a shot 3 times a week. A slow release form of interferon, pegylated interferon (also known as peginterferon), is given as a shot once a week. Peginterferon is used more often than interferon to treat hepatitis B. Treatment with interferons can last 4 months to 1 year.
Interferons are used to treat long-term (chronic) HBV infection in adults and children who are at risk for liver disease. The American Association for the Study of Liver Disease has made recommendations on who should receive treatment for hepatitis B based on the presence of hepatitis B antigen in your blood, the level of hepatitis B virus DNA (HBV DNA) in your blood, and the levels of your liver enzymes.2
Treatment with interferons is not recommended if you are using illegal drugs or drinking too much alcohol. It is also not recommended if you have had an organ transplant or if you have advanced liver scarring (cirrhosis).
It is important to weigh the benefits of treatment against the risks. Treatment for HBV infection is considered successful if blood tests show that the virus is no longer multiplying in the body, if liver enzyme levels return to normal, and if liver damage (such as inflammation and scarring) improves.
The success of interferon treatment for hepatitis B depends on how treatment success is defined. Relapse—when the virus starts to multiply again—is common after treatment is stopped. Interferons stop the growth of the virus over the long term in about 35% of people who use them.2 Recent studies suggest that peginterferon works a little better than interferon.3, 4
Interferons work best for people who have high levels of liver enzymes and in whom the virus is multiplying. They are also more likely to work in people who have a strong immune system, who have had hepatitis for a short amount of time, and who became infected after childhood.1
Interferons have common side effects, including:
Rare side effects include:
See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)
- Malik AH, Lee WM (2000). Chronic hepatitis B virus infection: Treatment strategies for the next millennium. Annals of Internal Medicine, 132(9): 723–731.
- Lok ASF, McMahon BJ (2007). Chronic hepatitis B. Hepatology, 45(2): 507–539.
- Janssen, H (2005). Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: A randomised trial. Lancet, 365(9454): 123–129.
- Lau GKK, et al. (2005). Peginterferon alfa-2a, lamivudine, and the combination for HBeAG-positive chronic hepatitis B. New England Journal of Medicine, 352(26): 2682–2695.
|Primary Medical Reviewer||Anne C. Poinier, MD - Internal Medicine|
|Primary Medical Reviewer||Kathleen Romito, MD - Family Medicine|
|Specialist Medical Reviewer||E. Gregory Thompson, MD - Internal Medicine|
|Specialist Medical Reviewer||Steven L. Flamm, MD, MD - Gastroenterology|
|Last Revised||November 11, 2010|
Last Revised: November 11, 2010
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