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Raloxifene is taken in pill form every day. It can be taken at any time during the day. It is used only for postmenopausal women.
Raloxifene is a selective estrogen receptor modulator (SERM), which works like estrogen on bone. It also works like an "anti-estrogen" on breast tissue and the uterus. As a result, raloxifene:
Raloxifene is used to prevent and treat osteoporosis in women.
Raloxifene can also be used to help prevent breast cancer in women who have a high risk for breast cancer.
Bone. Studies show that raloxifene increases bone mineral density in the bones of the spine and neck. This lowers the risk for broken spinal bones.1 Although raloxifene works much like estrogen, it may not be as effective on bone.
Breast cancer. Among high-risk women, raloxifene lowers the risk of breast cancer about as much as tamoxifen does.2
All medicines have side effects. But many people don't feel the side effects, or they are able to deal with them. Ask your pharmacist about the side effects of each medicine you take. Side effects are also listed in the information that comes with your medicine.
Here are some important things to think about:
Call 911 or other emergency services right away if you have:
Call your doctor right away if you have:
Common side effects of this medicine include:
See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)
Raloxifene raises your risk of dangerous blood clots. So does bed rest. If you plan to have a surgery followed by bed rest, talk to your doctor about ways to reduce the risk of blood clots around the time of surgery.
Do not take raloxifene if you are taking certain medicines, such as cholestyramine, to lower the amounts of cholesterol in your blood, or if you have liver disease.
Medicine is one of the many tools your doctor has to treat a health problem. Taking medicine as your doctor suggests will improve your health and may prevent future problems. If you don't take your medicines properly, you may be putting your health (and perhaps your life) at risk.
There are many reasons why people have trouble taking their medicine. But in most cases, there is something you can do. For suggestions on how to work around common problems, see the topic Taking Medicines as Prescribed.
Do not use this medicine if you are pregnant or planning to get pregnant. If you need to use this medicine, talk to your doctor about how you can prevent pregnancy.
There are not good studies that show whether or not the drug can harm a baby through breast-feeding. Talk to your doctor before taking this drug if you are breast-feeding.
Follow-up care is a key part of your treatment and safety. Be sure to make and go to all appointments, and call your doctor if you are having problems. It's also a good idea to know your test results and keep a list of the medicines you take.
- Drugs for postmenopausal osteoporosis (2008). Treatment Guidelines From The Medical Letter, 6(74): 67–74.
- Vogel VG, et al. (2006). Effects of tamoxifen vs. raloxifene on the risk of developing invasive breast cancer and other disease outcomes: The NASBP study of tamoxifen and raloxifene (STAR) P-2 trial. JAMA, 295(23): 2727–2741.
Last Revised: May 14, 2012
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