Syphilis is a sexually transmitted infection (STI) caused by the bacterium Treponema pallidum. If it's not treated by a doctor, it can get worse over time and cause serious health problems.
The infection can be active at times and not active at other times. When the infection is active, you have symptoms. When it's not active, you don't have symptoms, even though you still have syphilis. But even when you don't have symptoms, you can pass syphilis to others.
You don't have to have sexual intercourse to get syphilis. Just being in close contact with an infected person's genitals, mouth, or rectum is enough to expose you to the infection.
Bacteria cause syphilis. They usually enter the body through the tissues that line the throat, nose, rectum, and vagina. A person with syphilis who has a sore or a rash can pass the infection to others. An infected pregnant woman can also pass syphilis to her baby.
Some things increase your chance of getting syphilis. They include:
You may not notice symptoms of syphilis. Sometimes they are the same as symptoms for other infections. This can cause someone with the infection to put off seeing a doctor. And it can make it harder for a doctor to tell if you have syphilis.
The four stages of syphilis have different symptoms.
If you have sores, bumps, a rash, blisters, or warts on or around your genital or anal area, or if you think you were exposed to an STI, see your doctor.
He or she will do a physical exam and will ask you about your symptoms and your sexual history. You will probably have one or more blood tests to check for the infection. Because the open sores from syphilis make HIV infection more likely, you may also be tested for HIV.
To prevent babies from getting syphilis, experts recommend that all pregnant women have a syphilis blood test.
Syphilis can be cured with antibiotics. Both you and any sex partners that you may have exposed to the infection will need to be treated.
It is important to know that syphilis is not a infection that you can treat on your own. It must be treated with medicine that only your doctor can give you. With treatment, you avoid other serious health problems. And treatment keeps you from spreading syphilis to others.
If a woman is pregnant and has untreated syphilis, it can cause miscarriage or stillbirth. It can also cause the baby to be born with the infection. This is called congenital syphilis.
At any stage of the infection, antibiotics work well to cure syphilis. They can't undo the damage already caused by late-stage syphilis. But they can help you avoid further problems from the infection.
There are some things you can do to prevent syphilis. Whether you have never had the infection or if you have had it before and are trying to keep from getting it again, it is important to practice safe sex. Safe sex includes using condoms and using them correctly.
Learning about syphilis:
Syphilis is caused by the bacterium Treponema pallidum.
Transmission of the bacteria usually occurs during vaginal, anal, or oral sex. The syphilis bacteria are passed from person to person through direct contact with:
Sores mainly occur on the external genitals, vagina, anus, or rectum. Sores can also occur on the lips and in or around the mouth. The bacteria most commonly enter the body through mucous membranes, usually in the area around the genitals and urinary system.
In rare cases, syphilis enters the body through openings in the skin, such as cuts and scrapes, or even through wet kisses, if the infected person has a sore on the mouth or lips. Syphilis may also be transmitted by using a needle previously used by an infected person. Syphilis can be transmitted through a blood transfusion. But this is very rare, because all donated blood in the United States and Canada is screened for some sexually transmitted infections (STIs). And syphilis bacteria cannot survive more than 24 to 48 hours in blood stored using modern blood-banking methods.
Syphilis cannot be spread through casual contact with toilet seats, door knobs, swimming pools, hot tubs, bathtubs, shared clothing, or eating utensils.
Having been infected with syphilis in the past does not protect a person from becoming infected again.
An incubation period is the time between exposure to a disease and the first symptom. A skin sore called a chancre is usually the first symptom of sexually transmitted syphilis. A chancre appears between 3 weeks to 3 months after a person has been infected with syphilis.1
A person with syphilis can easily pass the infection (is contagious) to physically intimate partners when primary- or secondary-stage sores are present. But the person may be contagious for years, off and on, and is always contagious whenever an open sore or skin rash from syphilis is present.
Syphilis develops in four stages, each with a different set of symptoms.
During the primary stage of syphilis, a sore (chancre) that is usually painless develops at the site where the bacteria entered the body. This commonly occurs within 3 weeks of exposure but can range from 10 to 90 days. A person is highly contagious during the primary stage.
Secondary syphilis is characterized by a rash that appears 2 to 8 weeks after the chancre develops and sometimes before it heals. Other symptoms may also occur, which means that the infection has spread throughout the body. A person is highly contagious during the secondary stage.
A rash often develops over the body and commonly includes the palms of the hands and the soles of the feet.
The skin rash usually heals within 2 months. on its own without scarring. After healing, skin discoloration may occur. But even though the skin rash has healed, syphilis is still present and a person can still pass the infection to others.1
When syphilis has spread throughout the body, the person may have:
If untreated, an infected person will progress to the latent (hidden) stage of syphilis. The latent stage is defined as the year after a person becomes infected. After the secondary-stage rash goes away, the person will not have any symptoms for a time (latent period). The latent period may be as brief as 1 year or range from 5 to 20 years.
Often during this stage, an accurate diagnosis can only be made through blood testing, the person's history, or the birth of a child with congenital syphilis.
A person is contagious during the early part of the latent stage and may be contagious during the latent period when no symptoms are present.
About 20 to 30 out of 100 people with syphilis have a relapse of the infection during its latent stage.2 A relapse means the person was symptom-free but then started having symptoms again. Relapses can occur several times.
When relapses no longer occur, a person is not contagious through contact. But a woman in the latent stage of syphilis may still pass the infection to her developing baby and may have a miscarriage or a stillbirth or give birth to a baby infected with congenital syphilis.
This is the most destructive stage of syphilis. If untreated, the tertiary stage may begin as early as 1 year after infection or at any time during a person's lifetime. A person with syphilis may never experience this stage of the illness.
During this stage, syphilis may cause serious blood vessel and heart problems, mental disorders, blindness, nerve system problems, and even death. The symptoms of tertiary (late) syphilis depend on the complications that develop. Complications of this stage include:
Congenital syphilis refers to syphilis passed from a mother to her baby during pregnancy or during labor and delivery. The U.S. Centers for Disease Control and Prevention (CDC) and the U.S. Preventive Services Task Force strongly recommend that all pregnant women be screened for syphilis because of the severe consequences of being pregnant while infected or having a child born with congenital syphilis. Screening should be done:3, 4
Congenital syphilis increases the risk of fetal death and medical complications in newborns. Syphilis enters the fetal blood system through the placenta, causing infection in the newborn or death of the fetus. Symptoms of congenital syphilis include:
Because there are other conditions with similar symptoms, an accurate diagnosis is important for treatment.
About 3 weeks—although the range is from 10 to 90 days—after a person is infected with syphilis, a sore (chancre) that is usually painless often appears on the genitals. This first stage in the course of syphilis is referred to as the primary stage. The chancre usually heals without treatment in 3 to 6 weeks.1
If syphilis is not treated during the primary stage, it often progresses to later stages.
In the secondary stage of syphilis, a skin rash will usually develop about 2 to 8 weeks after the chancre appears. The symptoms usually disappear without treatment within 2 months.1
After the rash clears, a person may have a period with no symptoms. This symptom-free period is called the latent (hidden) stage. Even though symptoms disappear, the bacteria that cause syphilis remain in the body and begin to damage the internal organs. The latent period may be as brief as 1 year or range from 5 to 20 years.
A person is contagious during the primary and secondary stages and may still be contagious during the early part of the latent stage. During this time, symptoms of the second stage of syphilis may reappear. This is called a relapse and can occur several times.
If not detected and treated, syphilis may then progress to the tertiary (late) stage, the most destructive stage of syphilis. During this stage, syphilis may cause serious blood vessel and heart problems, mental disorders, blindness, nerve system problems, and even death. It may begin as early as 1 year after infection or at any time during the infected person's life. About one-third of untreated people who are infected with syphilis will have the complications of tertiary (late) syphilis. Any organ system (such as the central nervous system) may become involved.
Complications of tertiary (late) syphilis include:
Congenital syphilis refers to syphilis passed from the mother to the baby during pregnancy or during labor and delivery. Congenital syphilis can cause complications in newborns and children.
Your risk of syphilis increases if you:
Syphilis is contagious whenever an open sore or skin rash is present. The risk of being infected with syphilis from a single sexual encounter with an infected partner is approximately 3% to 10%.6
Infection with syphilis also increases a person's risk of being infected with HIV. Syphilis causes open sores on the genitals that allow the HIV infection to enter the body easily. Syphilis is in general more common in people who are also infected with HIV.
Call to make an appointment if you:
In most areas, public health clinics or health departments are able to diagnose and provide low-cost assessment and treatment of early syphilis and other sexually transmitted infections (STIs).
For more information about symptoms of other sexually transmitted infections, see the topic Exposure to Sexually Transmitted Infections.
Watchful waiting, which means taking a wait-and-see approach, is not appropriate if you think you were exposed to or have syphilis or another sexually transmitted infection (STI). Any symptoms or other changes that suggest syphilis or another STI should be evaluated by a doctor. If you suspect a syphilis infection:
If you are diagnosed with syphilis, your sex partner(s) will need to be treated also.
All states require doctors to report newly diagnosed cases of syphilis (all stages) to health authorities.
Your primary doctor can diagnose and treat syphilis.
Health professionals who can diagnose and treat sexually transmitted infections (STIs) include:
In most areas, public health clinics or county health departments are able to diagnose and provide low-cost or free treatment of early syphilis and other STIs.
To prepare for your appointment, see the topic Making the Most of Your Appointment.
Diagnosis of syphilis includes a medical history and a physical exam. Your doctor may ask you questions such as:
The physical exam may include:
The diagnosis of syphilis is usually confirmed with one of several blood tests. This is especially true if no sores are present. If sores are present, a doctor may look at the fluid from one of the sores with a microscope to see whether syphilis bacteria are present (dark-field examination).
In newborns and children, a lumbar puncture may be done if:
Additional testing should be done to find out if other sexually transmitted infections are present, especially:
The diagnosis of syphilis can be delayed or complicated because its symptoms are very similar to those of many other diseases and are sometimes not recognized. Syphilis has historically been called "the great imitator."
Screening for syphilis is strongly recommended for pregnant women and for people who are at increased risk for the infection.
People at high risk of contracting syphilis include those who:
The U.S. Centers for Disease Control and Prevention (CDC) and the U.S. Preventive Services Task Force strongly recommend that pregnant women be screened for syphilis because of the severe consequences of being pregnant while infected or having a child born with congenital syphilis. Screening should be done:3, 4
Prompt treatment of syphilis is needed to cure the infection, prevent complications, and prevent the spread of the infection to others.
Penicillin is the preferred drug for treating syphilis. Penicillin is the standard therapy for the treatment of neurosyphilis, congenital syphilis, or syphilis acquired or detected during pregnancy. If you are allergic to penicillin, make sure you tell your doctor. Your doctor will still be able to treat the syphilis but may consult with a specialist on the best antibiotic choice.
The treatment of syphilis can be delayed or complicated because its symptoms are very similar to those of many other diseases and are sometimes not recognized. Syphilis has historically been called "the great imitator."
Self-care can effectively prevent an initial infection of or reinfection with syphilis or other sexually transmitted infections (STIs).
There is no home treatment for syphilis. It requires medicine prescribed by a doctor. Prescription antibiotic medicine normally cures syphilis infections. Syphilis does not cause long-term problems if it is treated before any complications develop. But syphilis can lead to many complications if it is not treated.
Make sure your partner knows that he or she needs to be treated even if there are no symptoms. You can spread the infection to others even if you do not have symptoms.
The treatment of syphilis and other sexually transmitted infections (STIs) is complex. If taken properly, antibiotic treatment with penicillin will usually cure a syphilis infection. If syphilis has progressed to the tertiary stage, antibiotics can prevent further complications. But they cannot reverse damage that has already occurred. Prompt antibiotic treatment will decrease complications and prevent the spread of the infection.
Exposed sex partners should be treated for syphilis. The chancres in syphilis can make transmission of HIV more likely. So testing for both syphilis and HIV should be done.
In rare cases, the first attempt at treatment does not cure the syphilis infection. Follow-up blood tests are needed to be sure the infection is cured.
|American Social Health Association|
|P.O. Box 13827|
|Research Triangle Park, NC 27709|
|Phone:||1-800-227-8922 (STI Resource Center Hotline)
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The mission of the American Social Health Association is to improve the health of individuals, families, and communities, with a focus on preventing sexually transmitted diseases and their harmful consequences.
|Centers for Disease Control and Prevention (CDC): National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention|
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The National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention is a branch of the Centers for Disease Control and Prevention (CDC). Their Web site provides information and updates on sexually transmitted diseases (STDs), human immunodeficiency virus (HIV), and tuberculosis (TB). You can also find fact sheets on these health topics.
|National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health|
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The National Institute of Allergy and Infectious Diseases conducts research and provides consumer information on infectious and immune-system-related diseases.
|Planned Parenthood Federation of America|
|434 West 33rd Street|
|New York, NY 10001|
The Planned Parenthood Federation of American provides comprehensive reproductive health care and consumer information about family planning, sexual health, and sexually transmitted diseases (STDs).
The Teen Talk Web site (www.plannedparenthood.org/teen-talk) has information for teens about dating, teen pregnancy, sexual orientation, gender identity, how teens can protect themselves against STDs, and more.
- Tramont EC (2010). Treponema pallidum (syphilis). In GL Mandell et al., eds., Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, 7th ed., vol. 2, pp. 3035–3058. Philadelphia: Churchill Livingstone Elsevier.
- Hook EW (2008). Syphilis. In L Goldman, D Ausiello, eds., Cecil Medicine, 23rd ed., pp. 2280–2288. Philadelphia: Saunders.
- Centers for Disease Control and Prevention (2010). Syphilis section of Sexually transmitted diseases treatment guidelines, 2010. MMWR, 59(RR-12): 1–110. Available online: http://www.cdc.gov/mmwr/preview/mmwrhtml/rr5912a1.htm?s_cid=rr5912a1_w.
- U.S. Preventive Services Task Force (2009). Screening for syphilis infection in pregnancy: U.S. Preventive Services Task Force reaffirmation recommendation statement. Annals of Internal Medicine, 150(10): 705–709.
- Centers for Disease Control and Prevention (2010). Sexually Transmitted Disease Surveillance 2009. Atlanta: U.S. Department of Health and Human Services. Available online: http://www.cdc.gov/std/stats09/default.htm.
- Eckert LO, Lentz GM (2007). Infections of the lower genital tract. In VL Katz et al., eds., Comprehensive Gynecology, 5th ed., pp. 569–606. Philadelphia: Mosby Elsevier.
Other Works Consulted
- American Academy of Pediatrics (2009). Syphilis. In LK Pickering et al., eds., Red Book: 2009 Report of the Committee on Infectious Diseases, 28th ed., pp. 638–651. Elk Grove Village, IL: American Academy of Pediatrics.
- Cox D, Ballard RC (2010). Syphilis. In SA Morse et al., eds., Atlas of Sexually Transmitted Diseases and AIDS, 4th ed., pp. 111–140. Philadelphia: Saunders.
- Lukehart SA (2008). Syphilis. In AS Fauci et al., eds., Harrison's Principles of Internal Medicine, 17th ed., vol. 1, pp. 1038–1046. New York: McGraw-Hill.
|Primary Medical Reviewer||Sarah Marshall, MD - Family Medicine|
|Specialist Medical Reviewer||Devika Singh, MD, MPH - Infectious Disease|
|Last Revised||September 29, 2011|
Last Revised: September 29, 2011
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