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ado-trastuzumab emtansine

Pronunciation: A doe tras TOOZ ue mab em TAN seen

Brand: Kadcyla

What is the most important information I should know about ado-trastuzumab emtansine?

Multum nopreg

Do not use ado-trastuzumab emtansine if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

Multum calldoc

Ado-trastuzumab emtansine can harm your liver. Call your doctor at once if you have upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).

Before you receive each ado-trastuzumab emtansine injection, your heart function may need to be checked using an electrocardiograph or ECG (sometimes called an EKG).

What is ado-trastuzumab emtansine?

Ado-trastuzumab emtansine is a cancer medication that interferes with the growth and spread of cancer cells in the body.

Ado-trastuzumab emtansine is used to treat a certain type of breast cancer that has spread to other parts of the body.

Ado-trastuzumab emtansine is usually given after other cancer medications have been tried without success.

Ado-trastuzumab emtansine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before receiving ado-trastuzumab emtansine?

Multum donot

You should not use ado-trastuzumab emtansine if you are allergic to it, or if you are pregnant.

To make sure ado-trastuzumab emtansine is safe for you, tell your doctor if you have:

  • bleeding or blood clotting disorder such as hemophilia; or
  • asthma, chronic obstructive pulmonary disease (COPD), sleep apnea, or other breathing disorder.
Multum nopreg

FDA pregnancy category D. Do not use ado-trastuzumab emtansine if you are pregnant. It could harm the unborn baby. Tell your doctor if you become pregnant during treatment. Use effective birth control while you are using this medication and for at least 6 months after your treatment ends.

You may need to have a negative pregnancy test before starting this treatment.

Multum nobrfeed

It is not known whether ado-trastuzumab emtansine passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

How is ado-trastuzumab emtansine given?

Before you receive this medicine, your doctor will perform blood tests to make sure ado-trastuzumab emtansine is the right medication to treat your cancer.

Ado-trastuzumab emtansine is injected into a vein through an IV. A healthcare provider will give you this injection.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when ado-trastuzumab emtansine is injected.

Ado-trastuzumab emtansine is usually given once every 3 weeks until your body no longer responds to the medication. Your doctor will determine how long to treat you with ado-trastuzumab emtansine.

Multum emt

You may need frequent medical tests at your doctor's office to be sure this medication is not causing harmful effects. Your cancer treatments may be delayed based on the results of these tests.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your ado-trastuzumab emtansine injection.

What happens if I overdose?

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while taking ado-trastuzumab emtansine?

Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.

Avoid coming into contact with your body fluids (including urine, feces, vomit, semen, vaginal fluid). This medicine can pass into body fluids. Patients or caregivers should wear rubber gloves while cleaning up body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.

Body fluids should not be handled by a woman who is pregnant or who may become pregnant. Use condoms during sexual activity to avoid exposure to body fluids.

What are the possible side effects of ado-trastuzumab emtansine?

Some side effects may occur during the injection. Tell your caregiver right away if you feel cold, light-headed, feverish or sweaty, or have chest tightness, rapid heartbeats, or trouble breathing.

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Multum calldoc

Call your doctor at once if you have:

  • nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • chest pain, dry cough, fever, wheezing, feeling short of breath;
  • shortness of breath (even with mild exertion), swelling, rapid weight gain;
  • pounding heartbeats or fluttering in your chest;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • numbness or tingling in your hands or feet;
  • fever, unusual weakness; or
  • blisters or ulcers in your mouth, red or swollen gums, trouble swallowing.

Common side effects may include:

  • constipation, diarrhea;
  • stomach pain, vomiting, dry mouth;
  • joint or muscle pain;
  • tired feeling; or
  • headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect ado-trastuzumab emtansine?

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with ado-trastuzumab emtansine, especially:

  • imatinib;
  • isoniazid;
  • nefazodone;
  • an antibiotic--clarithromycin, telithromycin;
  • antifungal medication--itraconazole, ketoconazole, posaconazole, voriconazole;
  • heart medication--nicardipine, quinidine;
  • hepatitis C medications--boceprevir, telaprevir; or
  • HIV/AIDS medication--atazanavir, delavirdine, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir.

This list is not complete. Other drugs may interact with ado-trastuzumab emtansine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

Your doctor or pharmacist can provide more information about ado-trastuzumab emtansine.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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