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rilpivirine

Pronunciation: RIL pi VIR een

Brand: Edurant

What is the most important information I should know about rilpivirine?

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You should not use rilpivirine if you are allergic to it.

Some medicines can interact with rilpivirine and should not be used at the same time. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Before you take rilpivirine, tell your doctor if you have liver disease (including hepatitis B or C), kidney disease, a history of depression or mental illness, or if you have ever taken any HIV medication in the past.

Do not take rilpivirine as your only HIV medication. Rilpivirine must be used in combination with other HIV medicines that your doctor has prescribed.

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Call your doctor at once if you have mood changes, anxiety, severe depression, feeling hopeless, or thoughts about suicide or hurting yourself.

Taking this medication will not prevent you from passing HIV to other people.

What is rilpivirine?

Rilpivirine is an antiviral medication that prevents human immunodeficiency virus (HIV) cells from multiplying in your body.

Rilpivirine is used to treat HIV, which causes the acquired immunodeficiency syndrome (AIDS). Rilpivirine is not a cure for HIV or AIDS.

Do not take rilpivirine as your only HIV medication. Rilpivirine must be used in combination with other HIV medicines that your doctor has prescribed.

Rilpivirine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking rilpivirine?

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You should not use rilpivirine if you are allergic to it.

Some medicines can cause unwanted or dangerous effects when used with rilpivirine. Your doctor may need to change your treatment plan if you use any of the following drugs:

  • carbamazepine, oxcarbazepine, phenobarbital, phenytoin;
  • rifabutin, rifampin, rifapentine;
  • esomeprazole, lansoprazole, omeprazole, pantoprazole, rabeprazole;
  • more than one dose of dexamethasone;
  • St John's wort; or
  • delavirdine, efavirenz, etravirine, nevirapine.
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Using any of these medicines while you are taking rilpivirine can cause serious medical problems or death.

To make sure rilpivirine is safe for you, tell your doctor if you have:

  • liver disease (including hepatitis B or C);
  • kidney disease;
  • a history of depression or mental illness; or
  • if you have ever taken any HIV medication in the past.

FDA pregnancy category B. Rilpivirine is not expected to harm an unborn baby, but HIV can be passed to your baby if you are not properly treated during pregnancy. Take all of your HIV medicines as directed to control your infection.

If you are pregnant, your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of rilpivirine on the baby.

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Women with HIV or AIDS should not breast feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.

How should I take rilpivirine?

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

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Rilpivirine is usually taken once per day with a meal. Always take the medicine with food.

Use rilpivirine regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

While using rilpivirine, you may need frequent blood tests at your doctor's office.

HIV/AIDS is usually treated with a combination of drugs. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice. Every person with HIV or AIDS should remain under the care of a doctor.

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Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

If you are less than 12 hours late in taking your medicine, take the missed dose with food as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

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Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking rilpivirine?

If you also take an antacid, take it at least 2 hours before or 4 hours after taking rilpivirine. Do not take an antacid and rilpivirine at the same time.

If you also take didanosine (Videx), take it at least 2 hours before or 4 hours after taking rilpivirine.

If you also take a stomach acid reducer, take it at least 12 hours before or 4 hours after taking rilpivirine. This includes cimetidine (Tagamet), famotidine (Pepcid), nizatidine (Axid), and ranitidine (Zantac). Do not take rilpivirine and this type of stomach medicine at the same time.

Taking this medication will not prevent you from passing HIV to other people. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

What are the possible side effects of rilpivirine?

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Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

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Call your doctor at once if you have:

  • mood changes, anxiety, severe depression, feeling hopeless, thoughts about suicide or hurting yourself;
  • fever, chills, cough with yellow or green mucus;
  • stabbing chest pain, wheezing, feeling short of breath;
  • nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
  • severe pain in your upper stomach spreading to your shoulder or back, stomach bloating, vomiting, sweating, fever, chills.

Common side effects may include:

  • sleep problems (insomnia), unusual dreams;
  • mild nausea, vomiting, stomach pain, diarrhea;
  • headache, dizziness;
  • mild skin rash;
  • tired feeling; or
  • changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect rilpivirine?

Many drugs can interact with rilpivirine. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment with rilpivirine, especially:

  • bosentan;
  • conivaptan;
  • imatinib;
  • methadone;
  • tacrolimus;
  • arsenic trioxide, vandetanib;
  • an antibiotic--azithromycin, clarithromycin, erythromycin, levofloxacin, moxifloxacin, nafcillin, pentamidine, telithromycin;
  • an antidepressant--amitriptyline, citalopram, clomipramine, desipramine, nefazodone;
  • antifungal medication--itraconazole, ketoconazole, posaconazole, voriconazole;
  • anti-malaria medication--chloroquine, halofantrine, mefloquine;
  • heart medication--amiodarone, dofetilide, disopyramide, dronedarone, flecainide, ibutilide, nicardipine, procainamide, propafenone, quinidine, sotalol;
  • hepatitis C medications--boceprevir, telaprevir;
  • HIV/AIDS medication--atazanavir, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir;
  • medicine to prevent or treat nausea and vomiting--dolasetron, droperidol, ondansetron;
  • medicine to treat a psychiatric disorder--chlorpromazine, clozapine, haloperidol, mesoridazine, pimozide, thioridazine, ziprasidone;
  • migraine headache medicine--sumatriptan, zolmitriptan; or
  • seizure medication--fosphenytoin, primidone.
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This list is not complete and there are many other medicines that can interact with rilpivirine, or make it less effective. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

Where can I get more information?

Your pharmacist can provide more information about rilpivirine.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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