pegloticase

Pronunciation: peg LOE ti kase

Brand: Krystexxa

What is the most important information I should know about pegloticase?

Multum donot

You should not receive pegloticase if you are allergic to it, or if you have a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency.

Some drugs can interact with pegloticase and should not be used at the same time, especially allopurinol (Zyloprim), probenecid (Benemid), or febuxostat (Uloric).

To make sure pegloticase is safe for you, tell your doctor if you have gout, congestive heart failure, other heart problems, or high blood pressure.

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You may be given other medications to prevent certain side effects of pegloticase. You may need to start taking these medications at least a week before you receive your pegloticase injection. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice.

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Tell your caregiver right away if you feel itchy, nervous, light-headed, short of breath, or have a fast heartbeat, chest discomfort, or redness of your skin when the medicine is injected into your vein.

What is pegloticase?

Pegloticase is an enzyme that metabolizes uric acid into a harmless chemical that is eliminated from the body in urine.

Pegloticase is used to treat chronic gout. Pegloticase is usually given after other gout medications have been tried without successful treatment of symptoms.

Pegloticase may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking pegloticase?

Multum donot

You should not receive pegloticase if you are allergic to it, or if you have a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency.

Some drugs can interact with pegloticase and should not be used at the same time. Tell your doctor about all other medications you use, especially:

  • allopurinol (Zyloprim);
  • probenecid (Benemid); or
  • febuxostat (Uloric).

To make sure pegloticase is safe for you, tell your doctor about your other medical conditions, especially:

  • gout;
  • congestive heart failure;
  • other heart problems; or
  • high blood pressure.
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FDA pregnancy category C. It is not known whether pegloticase will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

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It is not known whether pegloticase passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using pegloticase.

How should I take pegloticase?

Pegloticase is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting. Pegloticase must be given slowly, and the IV infusion can take at least 2 hours to complete.

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You may be given other medications to prevent certain side effects of pegloticase. You may need to start taking these medications at least a week before you receive your pegloticase injection. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice.

Pegloticase is usually given once every 2 weeks. Follow your doctor's dosing instructions very carefully.

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When you first start using pegloticase, you may have an increase in gout flares. Keep using the medication as directed and tell your doctor if your symptoms do not improve after 3 months of treatment.

Your doctor may recommend other gout medications during the first 6 months of your treatment with pegloticase.

To be sure this medication is helping your condition, your blood may need to be tested often. This will help your doctor determine how long to treat you with pegloticase. Visit your doctor regularly.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your pegloticase injection.

What happens if I overdose?

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Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking pegloticase?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of pegloticase?

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Some people receiving a pegloticase injection have had a reaction to the infusion (when the medicine is injected into the vein). Infusion reactions may also occur after the injection is given. Tell your caregiver right away if you feel itchy, nervous, light-headed, short of breath, or have a fast heartbeat, chest discomfort, or redness of your skin during the injection.

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Get emergency medical help if you have any of these signs of an allergic reaction: hives; wheezing, difficult breathing; swelling of your face, lips, tongue, or throat.

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Call your doctor at once if you have a serious side effect such as:

  • chest pain; or
  • flushing (warmth, redness, or tingly feeling).

Less serious side effects may include:

  • new gout flares;
  • nausea, vomiting, constipation;
  • easy bruising; or
  • stuffy nose, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect pegloticase?

There may be other drugs that can interact with pegloticase. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about pegloticase.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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