If you are experiencing a medical emergency please dial 911 immediately
Pronunciation: KOL a JEN ase klos TRID ee um HIS toe LIT ik um
Before you receive this medication, tell your doctor if you have a bleeding or blood clotting disorder, such as hemophilia.
The day after your injection, your doctor will need to examine your hand to see if your condition has improved. Avoid any strenuous activity using the treated hand until your doctor tells you to resume normal activities.
Tell your caregiver at once if you have a serious side effect in the treated hand, such as bruising, bleeding, swelling, redness, warmth, numbness, tingling, or sudden pain or loss of movement.
Call your doctor if you have fever, chills, body aches, flu symptoms, or swollen glands in your elbow or underarm.
Collagenase clostridium histolyticum is made from a mixture of proteins derived from a certain bacteria.
Collagenase clostridium histolyticum is used to treat Dupuytren's contracture in adults. This condition causes an abnormal thickening of the tissue in the palm of the hand. This condition may get worse over time and form a "cord" in your palm, causing a permanent bend in your finger.
Collagenase clostridium histolyticum may also be used for purposes not listed in this medication guide.
You should not use this medication if you are allergic to it.
To make sure you can safely receive this medication, tell your doctor if you have a bleeding or blood clotting disorder, such as hemophilia.
FDA pregnancy category B. Collagenase clostridium histolyticum is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
It is not known whether collagenase clostridium histolyticum passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
This medication is injected directly into the "cord" of the affected hand. A healthcare provider will give you this injection.
After your injection, do not touch or put pressure on the treated area of the hand for the rest of the day. Keep the treated hand elevated until bedtime.
The day after your injection, your doctor will need to examine your hand to see if your condition has improved. If you still have the cord, your doctor may try to break it by extending your treated finger.
Collagenase clostridium histolyticum is usually given once every 4 weeks and you may receive more than one injection at a time. Follow your doctor's dosing instructions very carefully.
You may need to wear a splint on your hand for a short time to keep your fingers straight, especially at night. You may also need to perform daily finger exercises. Follow your doctor's instructions.
Call your doctor if you have trouble bending the treated finger after the swelling goes down.
Call your doctor for instructions if you miss an appointment for your collagenase clostridium histolyticum injection.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
Overdose symptoms may include some of the serious side effects listed in this medication guide.
Until you visit your doctor the day after your injection, do not flex or extend the fingers of your treated hand. Doing so may cause the medicine to spread away from the treatment area, making it less effective.
Avoid any strenuous activity using the treated hand until your doctor tells you to resume normal activities.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Tell your caregiver at once if you have a serious side effect such as:
Less serious side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before you receive this medication, tell your doctor about all other medicines you have used within the past 7 days, especially medication used to prevent blood clots, such as:
This list is not complete and other drugs may interact with collagenase clostridium histolyticum. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Your doctor or pharmacist can provide more information about collagenase clostridium histolyticum.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2013 Cerner Multum, Inc. Version: 1.02. Revision date: 12/15/2010.
Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.