morphine and naltrexone

Pronunciation: MOR feen and nal TREX one

Brand: Embeda

What is the most important information I should know about morphine and naltrexone?

Multum donot

You should not use morphine and naltrexone if you have ever had an allergic reaction to a narcotic medicine, if you are having an asthma attack or if you have a bowel obstruction called paralytic ileus.

Multum donot

Do not use morphine and naltrexone if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Before taking morphine and naltrexone, tell your doctor if you have a breathing disorder, liver or kidney disease, low blood pressure, a thyroid disorder, curvature of the spine, gallbladder or pancreas disorders, a blockage in your stomach or intestines, Addison's disease, enlarged prostate, urination problems, a seizure disorder, a debilitating condition, mental illness, a history of head injury or brain tumor, or a history of alcoholism or drug addiction.

Multum nopreg

Morphine and naltrexone may cause addiction or withdrawal symptoms in a newborn if the mother takes the medication during pregnancy. Tell your doctor if you are pregnant or plan to become pregnant while using morphine and naltrexone.

Multum nobrfeed

You should not breast-feed while you are using morphine and naltrexone.

Multum dizzy

This medication may impair your thinking or reactions. Avoid driving or operating machinery until you know how morphine and naltrexone will affect you. Do not take morphine and naltrexone with other medicines that can make you sleepy or slow your breathing. Dangerous side effects may result.

Multum noalcohol

Do not drink alcohol while you are using this medication. Dangerous side effects or death can occur when alcohol is combined with morphine and naltrexone. Check your food and medicine labels to be sure these products do not contain alcohol.

Multum nocrush

Do not crush, chew, or dissolve the medicine pellets inside an extended-release capsule. If possible, swallow the pill whole. Crushing or chewing the medicine pellets would cause too much of the drug to be released at one time, which may cause a life-threatening overdose.

Never take morphine and naltrexone in larger amounts, or for longer than recommended by your doctor. Tell your doctor if the medicine seems to stop working as well in relieving your pain.

What is morphine and naltrexone?

Morphine is an opioid pain medication. An opioid is sometimes called a narcotic.

Naltrexone is a special narcotic drug that blocks the effects of other narcotic medicines and alcohol.

The combination of morphine and naltrexone is used to treat moderate to severe pain when around-the-clock pain relief is needed for a long time period.

Morphine and naltrexone may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking morphine and naltrexone?

Your dose needs may be different if you have recently used an opioid pain medicine and your body is tolerant to it. Opioid medicines include fentanyl (Actiq, Duragesic), hydromorphone (Dilaudid, Palladone), methadone (Methadose, Dolophine), morphine (Kadian, MS Contin, Oramorph), oxycodone (Oxycontin), oxymorphone (Opana), and many others. Talk with your doctor if you are not sure you are opioid-tolerant.

Multum donot

You should not use morphine and naltrexone if you have ever had an allergic reaction to a narcotic medicine, if you are having an asthma attack or if you have a bowel obstruction called paralytic ileus.

Multum donot

Do not use morphine and naltrexone if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

To make sure you can safely take morphine and naltrexone, tell your doctor if you have any of these other conditions:

  • asthma, COPD, sleep apnea, or other breathing disorder;
  • liver or kidney disease;
  • low blood pressure;
  • a thyroid disorder;
  • curvature of the spine;
  • a history of head injury or brain tumor;
  • gallbladder or pancreas disorders;
  • a blockage in your stomach or intestines;
  • an adrenal gland tumor or disorder (such as Addison's disease);
  • enlarged prostate, urination problems;
  • epilepsy or other seizure disorder;
  • any type of debilitating condition;
  • mental illness; or
  • a history of alcoholism or drug addiction.
Multum habit

Morphine and naltrexone may be habit forming and should be used only by the person for whom it was prescribed. Never share morphine and naltrexone with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.

Multum nopreg

FDA pregnancy category C. It is not known whether morphine and naltrexone will harm an unborn baby. Morphine and naltrexone may cause addiction or withdrawal symptoms in a newborn if the mother takes the medication during pregnancy. Tell your doctor if you are pregnant or plan to become pregnant while using morphine and naltrexone.

Multum nobrfeed

Morphine and naltrexone can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using morphine and naltrexone.

Older adults may be more sensitive to the effects of this medicine.

How should I use morphine and naltrexone?

Take exactly as prescribed. Never take morphine and naltrexone in larger amounts, or for longer than recommended by your doctor. Follow the directions on your prescription label. Tell your doctor if the medicine seems to stop working as well in relieving your pain.

You may take morphine and naltrexone with or without food. Morphine and naltrexone is usually taken 1 or 2 times each day. Each dose should be spaced at least 12 hours apart. Follow your doctor's instructions.

Multum nocrush

Do not crush, chew, or dissolve the medicine pellets inside an extended-release capsule. If possible, swallow the pill whole. Crushing or chewing the medicine pellets would cause too much of the drug to be released at one time, which may cause a life-threatening overdose.

To make swallowing easier, you may open the extended-release capsule and sprinkle the medicine into a spoonful of applesauce. Mix only one dose and swallow this mixture right away without chewing. Drink a glass of water to make sure all the medicine has been swallowed. Flush the empty capsule down a toilet.

Multum donot

Do not stop using morphine and naltrexone suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using morphine and naltrexone.

Multum rt

Store at room temperature away from moisture, heat, and light. Keep track of the amount of medicine used from each new bottle. Morphine and naltrexone is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

After you have stopped using this medication, flush any unused pills down the toilet. Throw away any unused liquid morphine and naltrexone that is older than 90 days.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Multum donot

Morphine and naltrexone is not for use on an as-needed basis for pain.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of morphine and naltrexone can be fatal.

Overdose symptoms may include severe forms of some of the side effects listed in this medication guide.

What should I avoid while using morphine and naltrexone?

Multum noalcohol

Do not drink alcohol while you are using this medication. Dangerous side effects or death can occur when alcohol is combined with morphine and naltrexone. Check your food and medicine labels to be sure these products do not contain alcohol.

Multum dizzy

This medication may impair your thinking or reactions. Avoid driving or operating machinery until you know how morphine and naltrexone will affect you.

What are the possible side effects of morphine and naltrexone?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; chest pain, anxiety, pounding heartbeats, fainting; swelling of your face, lips, tongue, or throat.

Multum donot

Call your doctor at once if you have a serious side effect such as:

  • mood changes, hallucinations, confusion, unusual thoughts or behavior;
  • weak or shallow breathing, feeling like you might pass out;
  • cold and clammy skin, blue lips or skin;
  • painful or difficult urination;
  • severe constipation or stomach pain; or
  • slow heart rate, weak pulse, fainting, slow breathing (breathing may stop).

Less serious side effects may include:

  • drowsiness, dizziness, anxiety, feeling tired;
  • dry mouth, nausea, vomiting, mild constipation, diarrhea;
  • blurred vision, headache;
  • sleep problems (insomnia); or
  • itching, sweating, or flushing (warmth, redness, or tingly feeling).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect morphine and naltrexone?

Multum dizzy

Do not take morphine and naltrexone with any other narcotic pain medications, sedatives, tranquilizers, sleeping pills, muscle relaxers, or other medicines that can make you sleepy or slow your breathing. Dangerous side effects may result. Tell your doctor if you regularly use any of these medications, or medicine for seizures, depression, or anxiety.

Tell your doctor about all other medicines you use, especially:

  • cimetidine (Tagamet),
  • ketoconazole (Nizoral);
  • atropine (Atreza, Sal-Tropine), belladonna (Donnatal, and others), benztropine (Cogentin), dimenhydrinate (Dramamine), methscopolamine (Pamine), or scopolamine (Transderm Scop);
  • bladder or urinary medicines such as darifenacin (Enablex), flavoxate (Urispas), oxybutynin (Ditropan, Oxytrol), tolterodine (Detrol), or solifenacin (Vesicare);
  • bronchodilators such as ipratropium (Atrovent) or tiotropium (Spiriva);
  • a diuretic (water pill);
  • heart or blood pressure medications, such as reserpine, quinidine (Quin-G), or verapamil (Calan, Covera, Isoptin, Verelan, Tarka);
  • HIV/AIDS medication such as nelfinavir (Viracept), ritonavir (Norvir, Kaletra), or saquinavir (Invirase);
  • irritable bowel medicines such as dicyclomine (Bentyl), hyoscyamine (Hyomax), or propantheline (Pro Banthine);
  • medicines used to prevent organ transplant rejection, such as cyclosporine (Gengraf, Neoral, Sandimmune) or tacrolimus (Prograf);
  • other pain medications such as buprenorphine (Buprenex, Butrans, Subutex), butorphanol (Stadol), nalbuphine (Nubain), or pentazocine (Talwin); or
  • ulcer medications such as glycopyrrolate (Robinul) or mepenzolate (Cantil).

This list is not complete and other drugs may interact with morphine and naltrexone. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about morphine and naltrexone.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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