heparin (flush)

Pronunciation: HEP a rin

Brand: Heparin Lock Flush, Monoject Prefill Advanced, PosiFlush

What is the most important information I should know about heparin flush?

Multum donot

Heparin flush should not be used to treat or prevent blood clots in the body. A separate heparin product is available to use for this purpose.

Multum donot

You should not use this medication if you are allergic to heparin flush, or if you have uncontrolled bleeding or a severe lack of platelets in your blood.

Before using heparin flush, tell your doctor if you have any type of allergy, high blood pressure, an infection involving your heart, hemophilia or other bleeding disorder, a stomach or intestinal disorder, kidney or liver disease, or if you are on your period.

Multum emt

Heparin flush can cause bleeding. Call your doctor at once if you have easy bruising or unusual bleeding, such as a nosebleed, black or bloody tarry stools, or any bleeding that will not stop.

Multum donot

Certain medicines can increase your risk of bleeding while you are using heparin flush, such as aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) including ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), ketoprofen (Orudis), ketorolac (Toradol), mefenamic acid (Ponstel), nabumetone (Relafen), piroxicam (Feldene), and others.

Multum donot

Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Women over 60 years of age may be more likely to have bleeding episodes while using heparin flush.

What is heparin flush?

Heparin is an anticoagulant (blood thinner) that prevents the formation of blood clots.

Heparin flush is used to flush (clean out) an intravenous (IV) catheter, which helps prevent blockage in the tube after you have received an IV infusion.

Multum donot

Heparin flush should not be used to treat or prevent blood clots in the body. A separate heparin product is available to use for this purpose.

Heparin flush may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking heparin flush?

Multum donot

You should not use this medication if you are allergic to heparin, or if you have:

  • a severe lack of platelets in your blood; or
  • uncontrolled bleeding.

To make sure you can safely use heparin flush, tell your doctor if you have any of these other conditions:

  • any type of allergy;
  • an infection of the lining of your heart (also called bacterial endocarditis);
  • uncontrolled high blood pressure;
  • recent history of heart attack, stroke, cancer, or surgery;
  • a bleeding or blood clotting disorder, such as hemophilia;
  • a stomach or intestinal disorder;
  • congestive heart failure;
  • kidney disease;
  • liver disease; or
  • if you are having a menstrual period.
Multum nopreg

FDA pregnancy category C. It is not known whether heparin flush will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

Multum nobrfeed

Do not use this medication without telling your doctor if you are breast-feeding a baby.

Women over 60 years of age may be more likely to have bleeding episodes while using heparin flush.

Do not use heparin flush in a newborn baby (less than 1 month old). Do not use this medication in any child without your doctor's advice.

How should I use heparin flush?

Heparin flush is injected directly into the catheter lock of your IV line. You may be shown how to use heparin flush at home.

Multum donot

Do not self-inject heparin flush if you do not fully understand how to give the medication and properly dispose of used needles, IV tubing, and other items used to inject the medicine. Follow your doctor's instructions.

Do not use the medication if it has changed colors or has particles in it. Call your doctor for a new prescription.

Multum rt

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose of heparin.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking heparin flush?

Multum donot

Certain medicines can increase your risk of bleeding while you are using heparin flush, such as aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) including ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), ketoprofen (Orudis), ketorolac (Toradol), mefenamic acid (Ponstel), nabumetone (Relafen), piroxicam (Feldene), and others.

What are the possible side effects of heparin flush?

Multum emt

Heparin flush can cause bleeding. Call your doctor at once if you have easy bruising or unusual bleeding, such as a nosebleed, black or bloody tarry stools, or any bleeding that will not stop.

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: nausea, vomiting, sweating, hives, itching, trouble breathing, swelling of your face, lips, tongue, or throat, or feeling like you might pass out..

Multum donot

Stop using heparin flush and call your doctor at once if you have any of these serious side effects:

  • feeling like you might pass out;
  • sudden numbness or weakness, especially on one side of the body;
  • sudden severe headache, confusion, problems with vision, speech, or balance;
  • chest pain, sudden cough, wheezing, rapid breathing, fast heart rate;
  • pain, swelling, warmth, or redness in one or both legs;
  • skin changes in your arms, legs, hands, or feet; or
  • (in an infant) extreme drowsiness, weakness, or gasping for breath.

Less serious side effects are more likely, and you may have none at all.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect heparin flush?

Tell your doctor about all other medicines you use, especially:

  • another blood thinner, such as warfarin (Coumadin, Jantoven);
  • cold or allergy medication that contains an antihistamine;
  • digoxin (digitalis, Lanoxin, Lanoxicaps);
  • dipyridamole (Persantine);
  • hydroxychloroquine (Plaquenil, Quineprox);
  • nicotine cigarettes, gum, lozenges, or skin patches;
  • nitroglycerin (Nitro Dur, Nitrolingual, Nitrostat, Transderm Nitro, and others);
  • an antibiotic such as demeclocycline (Declomycin), doxycycline (Adoxa, Alodox, Avidoxy, Oraxyl, Doryx, Oracea, Vibramycin), minocycline (Dynacin, Minocin, Solodyn), or tetracycline (Ala-Tet, Brodspec, Panmycin, Sumycin, Tetracap); or
  • salicylates such as aspirin, Nuprin Backache Caplet, Kaopectate, KneeRelief, Pamprin Cramp Formula, Pepto-Bismol, Tricosal, Trilisate, and others.

This list is not complete and other drugs may interact with heparin flush. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your doctor or pharmacist can provide more information about heparin flush.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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