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etravirine

Pronunciation: E tra VIR een

Brand: Intelence

What is the most important information I should know about etravirine?

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In rare cases, etravirine can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.

Etravirine must be taken in combination with other HIV medications. However, there are certain combinations of medicines that should not be used together with etravirine. Follow your doctor's dosing instructions very carefully.

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There are many other medicines that can interact with etravirine, or make it less effective. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

Use all medications as directed by your doctor. Do not change your doses or medication schedule without your doctor's advice. Every person with HIV or AIDS should remain under the care of a doctor.

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Taking this medication will not prevent you from passing HIV to other people. Avoid having unprotected sex or sharing razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

What is etravirine?

Etravirine is an antiviral medication that prevents human immunodeficiency virus (HIV) cells from multiplying in your body.

Etravirine is used with other medications to treat HIV in adults and children who are at least 6 years old. HIV causes the acquired immunodeficiency syndrome (AIDS). Etravirine is not a cure for HIV or AIDS.

Etravirine is usually given after other antiviral drugs have been tried without successful treatment of HIV.

Etravirine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking etravirine?

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You should not take etravirine if you are allergic to it.

To make sure you can safely take etravirine, tell your doctor if you have any liver disease, including hepatitis B or C.

Etravirine must be taken in combination with other HIV medications. However, there are certain combinations of medicines that should not be used together with etravirine. Follow your doctor's dosing instructions very carefully.

You SHOULD NOT take etravirine together with:

  • delavirdine (Rescriptor);
  • efavirenz (Sustiva, Atripla);
  • nevirapine (Viramune);
  • rifabutin (Mycobutin), rifapentine (Priftin), or rifampin (Rifadin, Rifater, Rifamate, Rimactane);
  • rilpivirine (Edurant);
  • St. John's wort;
  • atazanavir (Reyataz) given with ritonavir (Norvir);
  • fosamprenavir (Lexiva) given with ritonavir (Norvir);
  • tipranavir (Aptivus) given with ritonavir (Norvir);
  • ritonavir (Norvir) in doses of more than 600 milligrams twice daily; or
  • seizure medications such as phenytoin (Dilantin), phenobarbital (Solfoton), or carbamazepine (Carbatrol, Equetro, Tegretol).

You MUST take etravirine together with ritonavir if you are also taking:

  • indinavir (Crixivan); or
  • nelfinavir (Viracept).

FDA pregnancy category B. Tell your doctor if you are pregnant or plan to become pregnant during treatment. HIV can be passed to your baby if you are not properly treated during pregnancy. Take all of your HIV medicines as directed to control your infection.

If you are pregnant, your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of etravirine on the baby.

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Women with HIV or AIDS should not breast-feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.

How should I take etravirine?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Etravirine must be taken in combination with other HIV medications. Follow your doctor's dosing instructions very carefully.

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Etravirine works best if you take it after a meal. Do not take it on an empty stomach.

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Do not crush, chew, or break an etravirine tablet. Swallow it whole with liquid such as water.

If you cannot swallow an etravirine tablet whole, place it into a glass of water and allow the tablet to disperse in the liquid. The tablet will not dissolve completely. Drink this mixture right away. To make sure you get the entire dose, add a little more liquid to the same glass, swirl gently and drink right away.

If a child is taking this medication, tell your doctor if the child has any changes in weight. Etravirine doses are based on weight in children.

Use etravirine regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice. Every person with HIV or AIDS should remain under the care of a doctor.

To be sure this medication is helping your condition, your blood will need to be tested often. Visit your doctor regularly.

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Store at room temperature away from moisture and heat. Keep the tablets in their original container, along with the packet of moisture-absorbing preservative that comes with the medication.

What happens if I miss a dose?

If you are less than 6 hours late in taking your medicine, take the missed dose after your next meal. Then return to your regular dosing schedule. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

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Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking etravirine?

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Taking this medication will not prevent you from passing HIV to other people. Avoid having unprotected sex or sharing razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

What are the possible side effects of etravirine?

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Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

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In rare cases, etravirine can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.

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Stop taking etravirine and call your doctor at once if you have a serious side effect such as:

  • fever, chills, muscle weakness, joint or muscle pain, mouth sores, feeling very tired, or any other signs of new infection;
  • chest pain, feeling short of breath;
  • confusion, seizure;
  • urinating less than usual or not at all, swelling, rapid weight gain;
  • rapid heart rate, increased sweating, tremors, sleep problems (insomnia), feeling anxious or irritable;
  • severe diarrhea, unexplained weight loss, menstrual changes, impotence, loss of interest in sex;
  • swelling in your neck or throat (enlarged thyroid);
  • weakness or prickly feeling in your fingers or toes;
  • problems with balance or eye movement, trouble speaking or swallowing;
  • severe lower back pain, loss of bladder or bowel control;
  • nausea, upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • the first sign of any type of skin rash, no matter how mild; or
  • severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Less serious side effects may include:

  • numbness or tingly feeling in your hands or feet;
  • dizziness, drowsiness;
  • blurred vision;
  • upset stomach, constipation, heartburn, dry mouth;
  • unusual dreams; or
  • changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect etravirine?

There are many other medicines that can interact with etravirine, or make it less effective. Below is just a partial list. Tell your doctor if you are using any of the following drugs:

  • a blood thinner such as warfarin (Coumadin, Jantoven);
  • clarithromycin (Biaxin);
  • clopidogrel (Plavix);
  • cyclosporine (Gengraf, Neoral, Sandimmune);
  • dexamethasone (Cortastat, Decadron, Dexasone, Hexadrol, Solurex, and others);
  • diazepam (Valium);
  • maraviroc (Selzentry);
  • sildenafil (Viagra, Revatio), tadalafil (Cialis, Adcirca), or vardenafil (Levitra);
  • sirolimus (Rapamune), tacrolimus (Prograf);
  • an antifungal medication such as fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), or voriconazole (Vfend);
  • a cholesterol medication such as atorvastatin (Lipitor), fluvastatin (Lescol), lovastatin (Mevacor, Altoprev, Advicor), pravastatin (Pravachol), rosuvastatin (Crestor), or simvastatin (Zocor, Simcor, Vytorin, Juvisync);
  • a heart rhythm medication such as amiodarone (Cordarone, Pacerone), digoxin (digitalis, Lanoxin), disopyramide (Norpace), flecainide (Tambocor), mexiletine (Mexitil), propafenone (Rythmol), or quinidine (Quin-G); or
  • narcotic medication such as buprenorphine (Buprenex, Subutex), naloxone (Suboxone), or methadone (Diskets, Dolophine, Methadose).

This list is not complete and other drugs may interact with etravirine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

Where can I get more information?

Your pharmacist can provide more information about etravirine.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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