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Pronunciation: nye LOE ti nib
You should not use nilotinib if you are allergic to it, or if you have low blood levels of potassium or magnesium, or a history of Long QT syndrome.
Before using nilotinib, tell your doctor if you have heart disease or a heart rhythm disorder, liver disease, a personal history of pancreatitis, a family history of Long QT syndrome, or if your stomach has been surgically removed (total gastrectomy).
There may be other drugs that could interact with nilotinib, or some that should not be used at the same time. Tell your doctor about all other medications you use.
Do not use this medication without telling your doctor if you are pregnant or breast-feeding a baby.
While using nilotinib, you may need frequent blood tests at your doctor's office.
Call your doctor at once if you have a serious side effect such as feeling light-headed with a fast or pounding heartbeat, pale skin, easy bruising or bleeding, fever, flu symptoms, cough with stabbing chest pain, mouth sores, feeling light-headed or short of breath, swelling, sudden headache or vision problems, upper stomach pain, dark urine, or jaundice (yellowing of the skin or eyes).
Nilotinib interferes with the growth of some cancer cells.
Nilotinib is used to treat a type of blood cancer called Philadelphia chromosome positive chronic myeloid leukemia (CML).
Nilotinib may also be used for purposes not listed in this medication guide.
You should not use nilotinib if you are allergic to it, or if you have:
To make sure nilotinib is safe for you, tell your doctor if you have any of these conditions:
FDA pregnancy category D. Do not use nilotinib if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.
It is not known whether nilotinib passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are taking nilotinib.
Nilotinib capsules may contain lactose. Talk to your doctor before using this medication if you have galactose intolerance, or severe problems with lactose (milk sugar).
Nilotinib is usually taken every 12 hours. Follow the directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Take nilotinib on an empty stomach, at least 1 hour before or 2 hours after a meal. Do not take with food.
Take this medicine with a full glass of water.
Swallow the nilotinib capsule whole.
To make swallowing easier, you may open the nilotinib capsule and sprinkle the medicine into 1 teaspoon of applesauce. Swallow right away without chewing. Do not save the mixture for later use.
You will need frequent medical tests at your doctor's office to be sure this medication is not causing harmful effects. Your cancer treatments may be delayed based on the results of these tests.
Do not stop using nilotinib or change your dose without talking to your doctor. If you stop taking the medication too soon, your condition may get worse.
Store at room temperature away from moisture and heat.
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include drowsiness and vomiting.
Do not take with food. Food can increase your blood levels of nilotinib and may increase your risk of harmful side effects.
Grapefruit and grapefruit juice may interact with nilotinib and lead to unwanted side effects. Discuss the use of grapefruit products with your doctor.
Avoid taking an antacid within several hours before or after you take nilotinib.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using nilotinib and call your doctor at once if you have a serious side effect such as:
Other common side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Many drugs can interact with nilotinib and not all possible interactions are listed in this medication guide. Tell your doctor about all medications you use, and those you start or stop using during your treatment with nilotinib, especially:
This list is not complete and many other drugs can interact with nilotinib. This includes prescription, over-the-counter, vitamin, and herbal products. Give a list of all your medicines to any healthcare provider who treats you
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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