|Pronunciation:||nye LOE ti nib|
|You should not use nilotinib if you are allergic to it, or if you have low blood levels of potassium or magnesium, or a history of Long QT syndrome.|
|Do not use nilotinib if you are pregnant. It could harm the unborn baby.|
|You should not breast-feed while you are taking nilotinib.|
Before using nilotinib, tell your doctor if you have heart disease or a heart rhythm disorder, liver disease, a personal history of pancreatitis, a family history of Long QT syndrome, or if your stomach has been surgically removed (total gastrectomy).
|There are many other drugs that can cause serious or life-threatening medical problems if you take them together with nilotinib. Tell your doctor about all medications you use.|
You will need regular medical tests to be sure this medication is not causing harmful effects. Your cancer treatments may be delayed based on the results of these tests. Visit your doctor regularly.
Call your doctor at once if you have a serious side effect such as feeling light-headed with a fast or pounding heartbeat, pale skin, easy bruising or bleeding, fever, flu symptoms, cough with stabbing chest pain, mouth sores, feeling light-headed or short of breath, swelling, sudden headache or vision problems, upper stomach pain, dark urine, or jaundice (yellowing of the skin or eyes).
Nilotinib interferes with the growth of some cancer cells.
Nilotinib is used to treat a type of blood cancer called Philadelphia chromosome positive chronic myeloid leukemia (CML).
Nilotinib may also be used for purposes not listed in this medication guide.
|You should not use nilotinib if you are allergic to it, or if you have:|
To make sure you can safely take nilotinib, tell your doctor if you have any of these other conditions:
|FDA pregnancy category D. Do not use nilotinib if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.|
|It is not known whether nilotinib passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are taking nilotinib.|
Nilotinib capsules may contain lactose. Talk to your doctor before using this medication if you have galactose intolerance, or severe problems with lactose (milk sugar).
Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
Nilotinib is usually taken every 12 hours. Follow your doctor's instructions.
|Take nilotinib on an empty stomach, at least 1 hour before or 2 hours after eating. Do not take nilotinib with food.|
|Take this medicine with a full glass of water.|
|Do not break or open a nilotinib capsule. Swallow the pill whole.|
You may open the nilotinib capsule and sprinkle the medicine into a spoonful of applesauce to make swallowing easier. Swallow right away without chewing. Do not save the mixture for later use. Discard the empty capsule.
|To be sure this medication is helping your condition and not causing harmful effects, your blood and bone marrow will need to be tested often. Your heart function will also need to be checked using an electrocardiograph or ECG (sometimes called an EKG). This machine measures electrical activity of the heart. Your cancer treatments may be delayed based on the results of these tests. Visit your doctor regularly.|
|Do not stop using nilotinib or change your dose without talking to your doctor. If you stop taking the medication too soon, your condition may get worse.|
|Store nilotinib at room temperature away from moisture and heat.|
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
|Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.|
Overdose may cause drowsiness or vomiting.
|Do not take with food. Food can increase your blood levels of nilotinib and may increase your risk of harmful side effects.|
Grapefruit and grapefruit juice may interact with nilotinib and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor.
|Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.|
|Stop using nilotinib and call your doctor at once if you have a serious side effect such as:|
Less serious side effects may be more likely to occur, such as:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Many drugs can interact with nilotinib. Below is just a partial list. Tell your doctor if you are using:
|This list is not complete and there are many other drugs that can cause serious or life-threatening medical problems if you take them together with nilotinib. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.|
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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