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Pronunciation: dye EN oh jest and ESS tra DYE ole
Do not use dienogest and estradiol if you are pregnant or if you have recently had a baby.
You should not take dienogest and estradiol if you have any of the following conditions: uncontrolled high blood pressure, heart disease, a blood-clotting disorder, circulation problems, diabetic problems with your eyes or kidneys, unusual vaginal bleeding, liver disease or liver cancer, severe migraine headaches, if you smoke and are over 35, or if you have ever had breast or uterine cancer, jaundice caused by birth control pills, a heart attack, a stroke, or a blood clot.
You may need to use back up birth control, such as condoms or a spermicide, when you first start using this medication or if you miss a dose. Follow your doctor's instructions.
Missing a pill increases your risk of becoming pregnant. Carefully follow the "missed dose" instructions if you forget to take your medicine.
Some drugs can make dienogest and estradiol less effective in preventing pregnancy, including antibiotics, hepatitis C medications, HIV/AIDS medications, seizure medications, or barbiturate sedatives. Tell your doctor about all other medications you use.
Dienogest and estradiol is a combination drug that contains female hormones that prevent ovulation (the release of an egg from an ovary). This medication also causes changes in your cervical mucus and uterine lining, making it harder for sperm to reach the uterus and harder for a fertilized egg to attach to the uterus.
Dienogest and estradiol is used as contraception to prevent pregnancy. Dienogest and estradiol is also used to treat heavy menstrual bleeding that is not caused by any medical condition of the uterus.
Dienogest and estradiol may also be used for purposes not listed in this medication guide.
This medication can cause birth defects. Do not use if you are pregnant. Tell your doctor right away if you become pregnant, or if you miss two menstrual periods in a row. If you have recently had a baby, wait at least 4 weeks before taking dienogest and estradiol.
You should not take dienogest and estradiol if you have:
To make sure you can safely take dienogest and estradiol, tell your doctor if you have any of these other conditions:
The hormones in dienogest and estradiol can pass into breast milk and may harm a nursing baby. This medication may also slow breast milk production. Do not use if you are breast feeding a baby.
This medication contains 5 different colors of pills. Take 1 pill each day in the exact order directed on the blister pack. Use a back-up birth control, such as condoms or a spermicide, for the first 9 days when you first start using this medication. Do not take two different kinds of birth control pills at the same time.
If you are switching from another birth control pill, start taking dienogest and estradiol on the first day of your withdrawal bleeding. If you were taking progestin-only pills, start taking dienogest and estradiol on the day you would have taken your next pill.
If you are switching from a birth control implant, intrauterine device (IUD), vaginal ring, or skin patch, start taking dienogest and estradiol on the day the other birth control device is removed.
If you are switching from a birth control injection, start taking dienogest and estradiol on the day you would have received your next scheduled injection.
You may have breakthrough bleeding. Tell your doctor if this bleeding continues or is very heavy. You may also have very little or no bleeding during your periods.
If you need surgery or medical tests or if you will be on bed rest, you may need to stop using this medication for a short time. Any doctor or surgeon who treats you should know that you are using dienogest and estradiol.
Store this medication at room temperature away from moisture and heat.
Follow the patient instructions provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions. Missing a pill increases your risk of becoming pregnant.
If you miss one pill:
If you miss two pills:
If you miss a period for two months in a row, call your doctor because you might be pregnant.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include nausea, vomiting, and vaginal bleeding.
Smoking can increase your risk of blood clots, stroke, or heart attack caused by dienogest and estradiol, especially if you are older than 35.
This medication will not protect you from sexually transmitted diseases--including HIV and AIDS. Using a condom is the only way to protect yourself from these diseases.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using dienogest and estradiol and call your doctor at once if you have a serious side effect such as:
Less serious side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Some drugs can make dienogest and estradiol less effective, which may result in pregnancy. Tell your doctor if you are using any of the following drugs:
Tell your doctor about all other medicines you use, especially:
This list is not complete and other drugs may interact with dienogest and estradiol. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Your pharmacist can provide more information about dienogest and estradiol.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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