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lubiprostone

Pronunciation: loo bee PROS tone

Brand: Amitiza

What is the most important information I should know about lubiprostone?

Lubiprostone is used to treat chronic constipation in adults. It is also used to treat irritable bowel syndrome in women with constipation as the main symptom.

Multum food

Take lubiprostone with food or milk.

Multum donot

Do not take lubiprostone if you have severe diarrhea. Call your doctor for instructions.

Multum nobrfeed

A nursing baby could develop diarrhea if the mother takes lubiprostone while breast-feeding. Tell your doctor if you are breast-feeding a baby, and talk with your doctor if the baby develops diarrhea.

You may have tightness in your chest or feel short of breath within 1 hour after taking lubiprostone. This side effect should go away within 3 hours, but it may occur again when you take your next dose. Talk with your doctor if this side effect becomes bothersome.

Multum calldoc

Call your doctor at once if you have severe or ongoing nausea or diarrhea.

What is lubiprostone?

Lubiprostone increases the secretion of fluid in your intestines to help make it easier to pass stools (bowel movements).

Lubiprostone is used to treat chronic constipation in adults. It is also used to treat irritable bowel syndrome in women with constipation as the main symptom.

Lubiprostone may also be used for purposes not listed in this medication guide.

What should I discuss with my health care provider before taking lubiprostone?

Multum donot

You should not use this medication if you have a blockage in your digestive tract, or if you have severe diarrhea.

To make sure lubiprostone is safe for you, tell your doctor if you have any other cause for obstruction in your gastrointestinal (digestive) system, such as:

  • gallstones;
  • Crohn's disease;
  • Hirschsprung's disease;
  • impacted bowel movement;
  • diverticulitis, polyps; or
  • a history of hernia.

Also tell your doctor if you have liver disease.

Multum nopreg

FDA pregnancy category C. It is not known whether lubiprostone will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

Multum nobrfeed

It is not known whether lubiprostone passes into breast milk or if it could harm a nursing baby. However, a nursing baby could develop diarrhea if the mother takes lubiprostone while breast-feeding. Tell your doctor if you are breast-feeding a baby, and talk with your doctor if the baby develops diarrhea.

Multum nochild

Lubiprostone should not be given to a child.

How should I take lubiprostone?

Lubiprostone is usually taken twice daily. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Multum food

Take lubiprostone with food or milk.

Multum water

Drink a full glass of water when you take this medication.

You may have tightness in your chest or feel short of breath within 1 hour after taking lubiprostone. This side effect should go away within 3 hours, but it may occur again when you take your next dose. Talk with your doctor if this side effect becomes bothersome.

Multum donot

Do not take lubiprostone if you have severe diarrhea. Call your doctor for instructions.

Multum rt

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking lubiprostone?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of lubiprostone?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Multum calldoc

Call your doctor at once if you have severe or ongoing nausea or diarrhea.

Common side effects may include:

  • mild nausea, stomach pain;
  • mild diarrhea, gas, bloating; or
  • headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect lubiprostone?

Other drugs may interact with lubiprostone, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about lubiprostone.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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