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sunitinib

Pronunciation: soo NIT in ib

Brand: Sutent

Sutent 12.5 mg

capsule, orange, imprinted with Pfizer, STN 12.5 mg

Image of Sutent 12.5 mg
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Sutent 50 mg

capsule, brown, imprinted with Pfizer, STN 50 mg

Image of Sutent 50 mg
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What is the most important information I should know about sunitinib?

Multum nopreg

Do not use sunitinib if you are pregnant. It could harm the unborn baby.

Before using sunitinib, tell your doctor if you have liver or kidney disease, heart disease, high blood pressure, seizures, a bleeding or blood-clotting disorder, a thyroid or adrenal gland disorder, or if you have ever had a stroke, heart attack, congestive heart failure, a blood clot, or coronary artery disease.

Multum emt

If you need surgery or a dental procedure, tell the surgeon or dentist ahead of time that you are using sunitinib. You may need to stop using the medicine for a short time.

To be sure this medication is helping your condition and not causing harmful effects, you will need medical tests at the beginning of each 4-week treatment cycle.

Multum emt

Stop using sunitinib and call your doctor at once if you have chest pain, severe dizziness or fainting, fast or pounding heartbeats, swelling, feeling short of breath, sudden numbness or weakness, vision or speech problems, easy bruising or bleeding, blood in your urine or stools, coughing up blood, weight changes, tiredness, missed menstrual periods, upper stomach pain, dark urine, or jaundice (yellowing of the skin or eyes).

Tell your doctor about all other medicines you use.

What is sunitinib?

Sunitinib is a cancer medication that interferes with the growth and spread of cancer cells in the body.

Sunitinib is used to treat certain types of advanced or progressive tumors of the digestive system, the pancreas, or the kidneys.

Sunitinib may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using sunitinib?

Multum donot

You should not use this medication if you are allergic to it.

To make sure you can safely take sunitinib, tell your doctor if you have any of these other conditions:

  • liver or kidney disease;
  • heart disease, high blood pressure, heart rhythm disorder;
  • seizures;
  • a bleeding or blood-clotting disorder;
  • a disorder of your thyroid or adrenal gland;
  • a personal or family history of Long QT syndrome; or
  • a history of stroke, heart attack, congestive heart failure, a blood clot, or coronary artery disease.
Multum donot

Some people using sunitinib have developed bone loss in the jaw, also called osteonecrosis of the jaw. Symptoms may include jaw pain, swelling, numbness, loose teeth, gum infection, or slow healing after injury or surgery involving the gums.

You may be more likely to develop osteonecrosis of the jaw if you have cancer or have been treated with chemotherapy, radiation, or steroids. Other conditions associated with osteonecrosis of the jaw include blood clotting disorders, anemia (low red blood cells), a pre existing dental problem, or taking medications to treat or prevent osteoporosis.

Multum nopreg

FDA pregnancy category D. Do not use sunitinib if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

Multum nobrfeed

It is not known whether sunitinib passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using sunitinib.

How should I take sunitinib?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results.

Sunitinib is usually taken once per day. Sunitinib is sometimes taken for 4 weeks followed by 2 weeks off the drug. Your doctor will determine how many complete treatment cycles you need based on your condition.

Sunitinib may be taken with or without food.

Multum nocrush

Do not crush, chew, or open a sunitinib capsule. Swallow it whole. The medicine from a crushed or broken pill can be dangerous if it gets on your skin. If this occurs, wash your skin with soap and water and rinse thoroughly.

To be sure this medication is helping your condition and not causing harmful effects, your blood and blood pressure may need to be tested at the beginning of each 4-week treatment cycle. Your heart function may also need to be tested with an electrocardiogram (ECG or EKG) on a regular basis, and you may also need frequent dental exams. Do not miss any follow-up visits to your doctor.

Multum emt

If you need surgery or a dental procedure, tell the surgeon or dentist ahead of time that you are using sunitinib. You may need to stop using the medicine for a short time.

Multum rt

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe forms of some of the side effects listed in this medication guide.

What should I avoid while taking sunitinib?

Grapefruit and grapefruit juice may interact with sunitinib and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor.

What are the possible side effects of sunitinib?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Multum donot

Stop using sunitinib and call your doctor at once if you have a serious side effect such as:

  • headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;
  • feeling short of breath (even with mild exertion), swelling in your ankles or feet;
  • sudden numbness or weakness, problems with vision, speech, or balance;
  • numbness or tingly feeling around your mouth;
  • slow heart rate, weak pulse, confusion;
  • muscle weakness, tightness, or contraction, overactive reflexes;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum);
  • lower back pain, blood in your urine;
  • urinating less than usual or not at all;
  • pain and swelling in your stomach, bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
  • nausea, upper stomach pain, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • missed menstrual periods;
  • feeling depressed or very tired, loss of appetite, diarrhea, weight gain or loss, hair loss, sweating, increased sensitivity to heat.
  • fever, white patches or sores inside your mouth or on your lips; or
  • redness, tenderness, sunburn-like peeling of the palms of your hands or the soles of your feet.

Less serious side effects may include:

  • unusual or unpleasant taste in the mouth;
  • cough;
  • mild nausea, vomiting, upset stomach;
  • constipation;
  • dry skin, changes in skin or hair color; or
  • joint pain, back pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect sunitinib?

Tell your doctor about all other medications you are using, especially:

  • dexamethasone (Cortastat, Dexasone, Solurex, DexPak);
  • imatinib (Gleevec);
  • isoniazid (for treating tuberculosis);
  • nefazodone;
  • St. John's wort;
  • an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), rifabutin (Mycobutin), rifampin (Rifadin, Rifater, Rifamate), rifapentine (Priftin), or telithromycin (Ketek);
  • antifungal medication such as itraconazole (Sporanox), ketoconazole (Nizoral), miconazole (Oravig), or voriconazole (Vfend);
  • a barbiturate such as phenobarbital (Solfoton), secobarbital (Seconal), and others;
  • heart or blood pressure medication such as nicardipine (Cardene) or quinidine (Quin-G);
  • HIV/AIDS medicine such as atazanavir (Reyataz), delavirdine (Rescriptor), efavirenz (Sustiva, Atripla), etravirine (Intelence), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), saquinavir (Invirase), or ritonavir (Norvir, Kaletra);
  • medicines to treat narcolepsy, such as armodafinil (Nuvigil) or modafinil (Progivil);
  • medication to treat osteoporosis or Paget's disease of bone, such as alendronate (Fosamax), etidronate (Didronel), ibandronate (Boniva), pamidronate (Aredia), risedronate (Actonel, Atelvia), tiludronate (Skelid), or zoledronic acid (Zometa, Reclast); or
  • seizure medication such as carbamazepine (Carbatrol, Equetro, Tegretol), felbamate (Felbatol), oxcarbazepine (Trileptal), phenytoin (Dilantin), or primidone (Mysoline).

This list is not complete and other drugs may interact with sunitinib. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about sunitinib.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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