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darifenacin

Pronunciation: dar e FEN a sin

Brand: Enablex

Enablex 15 mg

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Enablex 7.5 mg

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What is the most important information I should know about darifenacin?

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You should not use this medication if you are allergic to darifenacin, or if you have untreated or uncontrolled narrow-angle glaucoma, a blockage in your digestive tract (stomach or intestines), or if you are unable to urinate.

Before using darifenacin, tell your doctor if you have glaucoma, liver disease, a muscle disorder, ulcerative colitis, or a blockage in your stomach or intestines.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Darifenacin can decrease perspiration and you may be more prone to heat stroke.

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This medication may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

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There are many other medicines that can interact with darifenacin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

Stop using this medication and call your doctor if you have serious side effects such as hot and dry skin, extreme thirst, severe stomach pain or constipation, pain or burning when you urinate, or if you stop urinating.

What is darifenacin?

Darifenacin reduces muscle spasms of the bladder and urinary tract.

Darifenacin is used to treat symptoms of overactive bladder, such as frequent or urgent urination, and incontinence (urine leakage).

Darifenacin may also be used for purposes not listed in this medication guide.

What should I discuss with my health care provider before taking darifenacin?

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You should not use this medication if you are allergic to darifenacin, or have certain conditions. Be sure your doctor knows if you have:

  • untreated or uncontrolled narrow-angle glaucoma;
  • a stomach disorder causing delayed emptying; or
  • if you are unable to urinate.

To make sure you can safely take darifenacin, tell your doctor if you have any of these other conditions:

  • glaucoma;
  • liver disease;
  • ulcerative colitis;
  • a blockage in your stomach or intestines;
  • a muscle disorder such as myasthenia gravis; or
  • if you have very little urine or trouble emptying your bladder.
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FDA pregnancy category C. It is not known whether darifenacin will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

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It is not known whether darifenacin passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take darifenacin?

Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

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Take this medicine with water.

Darifenacin can be taken with or without food.

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Store darifenacin at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

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Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include severe constipation or stomach pain, extreme weakness, or urinating less than usual or not at all.

What should I avoid while taking darifenacin?

Avoid becoming overheated or dehydrated during exercise and in hot weather. Darifenacin can decrease perspiration and you may be more prone to heat stroke.

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Darifenacin can cause side effects that may impair your vision or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

What are the possible side effects of darifenacin?

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Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

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Stop using darifenacin and call your doctor at once if you have any of these serious side effects:

  • hot, dry skin and extreme thirst;
  • severe stomach pain or constipation;
  • confusion, hallucinations;
  • pain or burning when you urinate;
  • urinating less than usual or not at all;
  • severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Less serious side effects may include:

  • dry mouth;
  • dry eyes, blurred vision;
  • mild constipation;
  • diarrhea;
  • nausea, mild stomach pain or upset;
  • dizziness, weakness, drowsiness;
  • headache; or
  • fever, sore throat, body aches, or other flu symptoms.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect darifenacin?

The following drugs can interact with darifenacin. Tell your doctor if you are using any of these:

  • flecainide (Tambocor);
  • thioridazine (Mellaril);
  • atropine (Atreza, Sal-Tropine), belladonna (Donnatal, and others), benztropine (Cogentin), dimenhydrinate (Dramamine), methscopolamine (Pamine), or scopolamine (Transderm Scop);
  • an antibiotic such as clarithromycin (Biaxin) or erythromycin (E.E.S., E-Mycin, Ery-Tab, Erythrocin);
  • an antidepressant such as amitriptyline (Elavil, Vanatrip, Limbitrol), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan, Silenor), imipramine (Janimine, Tofranil), nefazadone, or nortriptyline (Pamelor);
  • an antifungal medication such as itraconazole (Sporanox) or ketoconazole (Nizoral);
  • bronchodilators such as ipratroprium (Atrovent) or tiotropium (Spiriva);
  • HIV/AIDS medicine such as nelfinavir (Viracept) or ritonavir (Norvir, Kaletra);
  • irritable bowel medicines such as dicyclomine (Bentyl), hyoscyamine (Hyomax), or propantheline (Pro Banthine);
  • other bladder or urinary medicines such as flavoxate (Urispas), oxybutynin (Ditropan, Oxytrol), tolterodine (Detrol), or solifenacin (Vesicare); or
  • ulcer medications such as glycopyrrolate (Robinul) or mepenzolate (Cantil).

This list is not complete and other drugs may interact with darifenacin. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about darifenacin.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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