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chlorpheniramine, dihydrocodeine, and pseudoephedrine

Pronunciation: klor fen EER a meen, dye hye droe KOE deen, soo doe e FED rin

Brand: Dihydro-CP, Hydro-Tussin DHC

What is the most important information I should know about chlorpheniramine, dihydrocodeine, and pseudoephedrine?

Multum donot

You should not use this medication if you are allergic to chlorpheniramine, dihydrocodeine, pseudoephedrine, or codeine, or if you have severe or uncontrolled high blood pressure, severe coronary artery disease, narrow-angle glaucoma, a stomach ulcer, a bowel obstruction called paralytic ileus, bladder obstruction or other urination problems, overactive thyroid, or asthma, pneumonia, or other breathing problems.

Before you take chlorpheniramine, dihydrocodeine, and pseudoephedrine, tell your doctor about all of your medical conditions and other medicines you use.

Multum nochild

Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

Multum donot

Do not take this medication with alcohol, other narcotic pain medications, sedatives, tranquilizers, muscle relaxers, or other medicines that can make you sleepy or slow your breathing. Dangerous side effects may result.

Multum habit

Dihydrocodeine may be habit-forming and should be used only by the person it was prescribed for. Keep the medication in a secure place where others cannot get to it.

Multum donot

Ask a doctor or pharmacist before using any other cold, cough, allergy, or pain medicine. Antihistamines, decongestants, and cough suppressants are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains an antihistamine, decongestant, or cough suppressant.

Multum dizzy

This medication may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

What is chlorpheniramine, dihydrocodeine, and pseudoephedrine?

Chlorpheniramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Dihydrocodeine is a narcotic cough suppressant similar to codeine. Dihydrocodeine affects the signals in the brain that trigger cough reflex.

Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of chlorpheniramine, dihydrocodeine, and pseudoephedrine is used to treat cough, sneezing, itching, watery eyes, runny nose, stuffy nose, and sinus congestion caused by allergies, the common cold, or the flu.

Chlorpheniramine, dihydrocodeine, and pseudoephedrine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking chlorpheniramine, dihydrocodeine, and pseudoephedrine?

Multum donot

You should not use this medication if you are allergic to chlorpheniramine, dihydrocodeine, pseudoephedrine, or codeine, or if you have:

  • severe or uncontrolled high blood pressure;
  • severe coronary artery disease;
  • narrow-angle glaucoma;
  • a stomach ulcer;
  • a bowel obstruction called paralytic ileus;
  • bladder obstruction or other urination problems;
  • overactive thyroid; or
  • asthma, pneumonia, or other breathing problems.
Multum donot

Do not use a cough or cold medicine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

To make sure you can safely take chlorpheniramine, dihydrocodeine, and pseudoephedrine, tell your doctor if you have any of these other conditions:

  • kidney or liver disease;
  • curvature of the spine;
  • heart disease or high blood pressure;
  • enlarged prostate or urination problems;
  • diabetes;
  • glaucoma;
  • a thyroid disorder;
  • COPD other breathing disorder;
  • a history of head injury or brain tumor;
  • epilepsy or other seizure disorder;
  • low blood pressure;
  • gallbladder disease;
  • Addison's disease or other adrenal gland disorders;
  • mental illness; or
  • a history of drug or alcohol addiction.
Multum habit

Dihydrocodeine may be habit forming and should be used only by the person it was prescribed for. Never share this medication with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.

Multum nopreg

FDA pregnancy category C. It is not known whether this medication will harm an unborn baby. Dihydrocodeine may cause addiction or withdrawal symptoms in a newborn if the mother takes the medication during pregnancy. Tell your doctor if you are pregnant or plan to become pregnant while using chlorpheniramine, dihydrocodeine, and pseudoephedrine.

Multum nobrfeed

This medicine can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using chlorpheniramine, dihydrocodeine, and pseudoephedrine.

How should I take chlorpheniramine, dihydrocodeine, and pseudoephedrine?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Cough or cold medicine is usually taken for only a short time until your symptoms clear up.

Multum nochild

Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

Measure the liquid form of this medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Multum donot

Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, or skin rash.

Multum emt

If you need surgery, tell the surgeon ahead of time if you have taken a cough or cold medicine within the past few days.

This medication can cause you to have unusual results with allergy skin tests. Tell any doctor who treats you that you are taking an antihistamine.

Multum rt

Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Since cough or cold medicine is taken when needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of dihydrocodeine can be fatal.

Overdose symptoms may include extreme dizziness or drowsiness, confusion, feeling restless or nervous, cold and clammy skin, warmth or tingly feeling, nausea, vomiting, slow or shallow breathing, slow heart rate, pinpoint pupils, seizure (convulsions), or fainting.

What should I avoid while taking chlorpheniramine, dihydrocodeine, and pseudoephedrine?

Multum dizzy

This medication may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

Avoid becoming overheated or dehydrated during exercise and in hot weather.

Multum noalcohol

Drinking alcohol can increase certain side effects of chlorpheniramine, dihydrocodeine, and pseudoephedrine.

Multum donot

Do not take this medication with other narcotic pain medications, sedatives, tranquilizers, muscle relaxers, or other medicines that can make you sleepy or slow your breathing. Life-threatening side effects may result.

Avoid taking diet pills, caffeine pills, or other stimulants (such as ADHD medications) without your doctor's advice. Taking a stimulant together with a decongestant can increase your risk of unpleasant side effects.

Multum donot

Ask a doctor or pharmacist before using any other cold, cough, allergy, or pain medicine. Antihistamines, decongestants, and cough suppressants are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains an antihistamine, decongestant, or cough suppressant.

What are the possible side effects of chlorpheniramine, dihydrocodeine, and pseudoephedrine?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Multum donot

Stop using this medicine and call your doctor at once if you have a serious side effect such as:

  • fast, pounding, or uneven heartbeats;
  • weak or shallow breathing, slow heartbeat;
  • severe dizziness, fainting, anxiety, restless feeling, nervousness, or tremor;
  • confusion, hallucinations, unusual thoughts or behavior;
  • easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms;
  • urinating less than usual or not at all; or
  • dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).

Less serious side effects may include:

  • blurred vision;
  • dry mouth;
  • nausea, vomiting, stomach pain, constipation, mild loss of appetite;
  • mild dizziness, drowsiness;
  • problems with memory or concentration;
  • ringing in your ears;
  • warmth, redness, or tingling under your skin;
  • feeling restless or excited (especially in children);
  • sleep problems (insomnia); or
  • skin rash or itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect chlorpheniramine, dihydrocodeine, and pseudoephedrine?

Tell your doctor about all other medicines you use, especially:

  • methyldopa (Aldomet);
  • cimetidine (Tagamet);
  • rifampin (Rifadin, Rifater, Rifamate, Rimactane);
  • zidovudine (Retrovir, AZT);
  • aspirin or salicylates (such as Disalcid, Doan's Pills, Dolobid, Salflex, Tricosal, and others);
  • a beta-blocker such as atenolol (Tenormin), carteolol (Cartrol), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal), sotalol (Betapace), timolol (Blocadren), and others;
  • antidepressants such as amitriptyline (Elavil), clomipramine (Anafranil), imipramine (Janimine, Tofranil), and others;
  • bladder or urinary medications such as oxybutynin (Ditropan, Oxytrol) or tolterodine (Detrol);
  • a diuretic (water pill), or blood pressure medication;
  • medication to treat irritable bowel syndrome;
  • medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), haloperidol (Haldol), mesoridazine (Serentil), pimozide (Orap), or thioridazine (Mellaril); or
  • seizure medication such as phenytoin (Dilantin) or phenobarbital (Luminal, Solfoton).

This list is not complete and other drugs may interact with chlorpheniramine, dihydrocodeine, and pseudoephedrine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about chlorpheniramine, dihydrocodeine, and pseudoephedrine.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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