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hydrocodone and ibuprofen

Pronunciation: hye dro KOE done and eye byoo PRO fen

Brand: Ibudone, Reprexain, Vicoprofen

Hydrocodone-Ibuprofen 7.5 mg-200 mg-AMN

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Hydrocodone-Ibuprofen 7.5 mg-200 mg-TEV

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Hydrocodone-Ibuprofen 7.5-200 mg-WAT

round, white, imprinted with IP 145

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Reprexain 5 mg-200 mg

oval, white, imprinted with IP 146

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Vicoprofen

round, white, imprinted with VP LOGO

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What is the most important information I should know about hydrocodone and ibuprofen?

Multum emt

This medicine may cause life-threatening heart or circulation problems such as heart attack or stroke, especially if you use it long term. Do not use hydrocodone and ibuprofen just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Get emergency medical help if you have chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.

Multum emt

This medicine may also cause serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and can occur without warning while you are taking hydrocodone and ibuprofen, especially in older adults.

Call your doctor at once if you have symptoms of stomach bleeding such as black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.

Multum donot

Ask a doctor or pharmacist before using any cold, allergy, or pain medication. Many medicines available over the counter contain aspirin or other medicines similar to hydrocodone and ibuprofen (such as ibuprofen, ketoprofen, or naproxen). Taking certain products together can cause you to get too much of this type of medication. Check the label to see if a medicine contains naproxen, aspirin, ibuprofen, ketoprofen, or naproxen.

Multum habit

Hydrocodone may be habit-forming and should be used only by the person for whom it was prescribed. Keep the medication in a secure place where others cannot get to it.

Multum noalcohol

Avoid drinking alcohol. It may increase your risk of stomach bleeding while taking ibuprofen.

What is hydrocodone and ibuprofen?

Hydrocodone is an opioid pain medication. An opioid is sometimes called a narcotic.

Ibuprofen is a non steroidal anti inflammatory drug (NSAID). This medicine works by reducing substances in the body that cause pain, fever, and inflammation.

The combination of hydrocodone and ibuprofen is used short-term to relieve severe pain. This medication is not for treating arthritis pain.

Hydrocodone and ibuprofen may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking hydrocodone and ibuprofen?

Multum donot

You should not use this medication if you are allergic to hydrocodone or ibuprofen (Advil, Motrin), or other NSAIDs such as Aleve, Naprosyn, Celebrex, Arthrotec, Cataflam, Voltaren, Indocin, Mobic, and others.

Do not use hydrocodone and ibuprofen just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Multum emt

This medicine may cause life-threatening heart or circulation problems such as heart attack or stroke, especially if you use it long term.

This medicine may also cause serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and can occur without warning while you are taking hydrocodone and ibuprofen, especially in older adults.

To make sure you can safely take hydrocodone and ibuprofen, tell your doctor if you have any of these other conditions:

  • heart disease, congestive heart failure, high blood pressure, or a history of heart attack, stroke, or blood clot;
  • asthma or other breathing disorders;
  • liver or kidney disease;
  • a history of head injury or brain tumor;
  • stomach or intestinal disorder, history of stomach ulcer or bleeding;
  • underactive thyroid, Addison's disease or other adrenal gland disorder;
  • curvature of the spine;
  • an enlarged prostate or problems with urination; or
  • mental illness or a history of drug or alcohol addiction.
Multum habit

Hydrocodone may be habit forming and should be used only by the person for whom it was prescribed. Never share hydrocodone and ibuprofen with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.

Multum nopreg

FDA pregnancy category C. Hydrocodone may cause breathing problems or addiction/withdrawal symptoms in a newborn. Taking ibuprofen during the last 3 months of pregnancy may harm the unborn baby. Do not take hydrocodone and ibuprofen during pregnancy unless your doctor has told you to.

Multum nobrfeed

It is not known whether hydrocodone and ibuprofen passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using hydrocodone and ibuprofen.

Older adults may be more likely to have side effects from this medicine.

How should I take hydrocodone and ibuprofen?

Take exactly as prescribed. Never take hydrocodone and ibuprofen in larger amounts, or for longer than recommended by your doctor. Follow the directions on your prescription label. Tell your doctor if the medicine seems to stop working as well in relieving your pain.

Multum emt

If you need surgery, tell the surgeon ahead of time that you are using hydrocodone and ibuprofen. You may need to stop using the medicine for a short time.

Multum rt

Store at room temperature away from moisture and heat.

Keep track of the amount of medicine used from each new bottle. Hydrocodone and ibuprofen is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

What happens if I miss a dose?

Since hydrocodone and ibuprofen is taken as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of hydrocodone and ibuprofen can be fatal.

Overdose symptoms may include extreme drowsiness, nausea, vomiting, dark urine, jaundice (yellowing of the skin or eyes), black or bloody stools, coughing up blood, urinating less than usual or not at all, confusion, ringing in your ears, pinpoint pupils, weak pulse, slow heart rate, blue lips, shallow breathing, or fainting.

What should I avoid while taking hydrocodone and ibuprofen?

Multum dizzy

This medication may impair your thinking or reactions. Avoid driving or operating machinery until you know how hydrocodone and ibuprofen will affect you.

Multum donot

Ask a doctor or pharmacist before using any cold, allergy, or pain medication. Many medicines available over the counter contain aspirin or other medicines similar to ibuprofen (such as ketoprofen or naproxen). Taking certain products together can cause you to get too much of this type of medication. Check the label to see if a medicine contains naproxen, aspirin, ibuprofen, ketoprofen, or naproxen.

Multum noalcohol

Avoid drinking alcohol. It may increase your risk of stomach bleeding while taking ibuprofen.

What are the possible side effects of hydrocodone and ibuprofen?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Multum donot

Stop using hydrocodone and ibuprofen and call your doctor at once if you have a serious side effect such as:

  • sudden numbness or weakness, sudden severe headache, confusion, problems with vision or speech;
  • chest pain, sudden cough, wheezing, rapid breathing, coughing up blood;
  • pain, swelling, warmth, or redness in one or both legs;
  • bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
  • swelling or rapid weight gain;
  • shallow breathing, slow heartbeat;
  • easy bruising or bleeding, feeling like you might pass out;
  • nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • fever, chills, headache, neck stiffness, increased sensitivity to light, purple spots on the skin, and/or seizure (convulsions); or
  • severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Less serious side effects may include:

  • headache, dizziness, drowsiness;
  • mild nausea, vomiting, upset stomach, constipation, diarrhea;
  • blurred vision; or
  • dry mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect hydrocodone and ibuprofen?

Multum dizzy

Before using hydrocodone and ibuprofen, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by hydrocodone and ibuprofen.

Tell your doctor about all other medicines you use, especially:

  • lithium (Eskalith, Lithobid);
  • methotrexate (Rheumatrex, Trexall);
  • antidepressants such as amitriptyline (Elavil, Vanatrip) or imipramine (Tofranil);
  • an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate);
  • aspirin or other NSAIDs, such as ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch), indomethacin (Indocin), meloxicam (Mobic), and others;
  • heart or blood pressure medication such as benazepril (Lotensin), enalapril (Vasotec), lisinopril (Prinivil, Zestril), quinapril (Accupril), ramipril (Altace), and others;
  • a bronchodilator (such as Atrovent, Spiriva), diuretics (water pills), steroid medicines, or blood thinners;
  • an injected narcotic medication such as pentazocine (Talwin), butorphanol (Stadol), or nalbuphine Nubain);
  • atropine (Atreza, Sal-Tropine), belladonna (Donnatal, and others), benztropine (Cogentin), dimenhydrinate (Dramamine), or scopolamine (Transderm Scop); or
  • bowel or bladder medicines such as darifenacin (Enablex), solifenacin (Vesicare), dicyclomine (Bentyl), and others.

This list is not complete and other drugs may interact with hydrocodone and ibuprofen. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about hydrocodone and ibuprofen.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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