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clomipramine

Pronunciation: kloe MI pra meen

Brand: Anafranil

Clomipramine 25 mg-MYL

capsule, orange/peach, imprinted with MYLAN 3025

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Clomipramine 25 mg-TEV

capsule, orange/white, imprinted with 93 956

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Clomipramine 50 mg-GG

capsule, white, imprinted with GG 823

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Clomipramine 50 mg-MYL

capsule, pink/yellow, imprinted with MYLAN 3050

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Clomipramine 50 mg-TEV

capsule, blue/white, imprinted with 93 958

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Clomipramine 50 mg-WAT

yellow, imprinted with WATSON595, 50MG

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Clomipramine 75 mg-MYL

capsule, orange/peach, imprinted with MYLAN 3075

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Clomipramine 75 mg-TEV

capsule, brown/white, imprinted with 93 960

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What is the most important information I should know about clomipramine?

Multum donot

You should not take this medication if you are allergic to clomipramine or to similar antidepressants such as amitriptyline, amoxapine, desipramine, doxepin, imipramine, nortriptyline, protriptyline, or trimipramine.

Do not use clomipramine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include furazolidone, isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

Multum emt

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

What is clomipramine?

Clomipramine is a tricyclic antidepressant. It affects chemicals in the brain that may become unbalanced.

Clomipramine is used to treat symptoms of obsessive-compulsive disorder (OCD) such as recurrent thoughts or feelings and repetitive actions.

Clomipramine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking clomipramine?

Multum donot

You should not take this medication if you are allergic to clomipramine or to similar antidepressants such as amitriptyline, amoxapine, desipramine, doxepin, imipramine, nortriptyline, protriptyline, or trimipramine.

Do not use clomipramine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include furazolidone, isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

To make sure clomipramine is safe for you, tell your doctor if you have any of these conditions:

  • liver disease;
  • kidney disease;
  • bipolar disorder (manic-depression), schizophrenia or other mental illness;
  • history of alcoholism;
  • history of seizures or head injury;
  • heart disease;
  • low blood pressure;
  • glaucoma;
  • overactive thyroid or adrenal gland tumor (pheochromocytoma or neuroblastoma);
  • urination problems; or
  • if you are being treated with methylene blue injection.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using clomipramine. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Multum nopreg

FDA pregnancy category C. It is not known whether clomipramine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

Multum nobrfeed

Clomipramine can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using this medication.

Multum nochild

Do not give clomipramine to anyone younger than 18 years old without the advice of a doctor.

How should I take clomipramine?

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Multum food

Take clomipramine with food to reduce stomach upset.

Multum finish

It may take up to 4 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve after 4 weeks of treatment.

If you need surgery, tell the surgeon ahead of time that you are using clomipramine. You may need to stop using the medicine for a short time.

Multum donot

Do not stop using clomipramine suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using clomipramine.

Multum rt

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of clomipramine can be fatal.

Overdose symptoms may include vomiting, fast or uneven heart rate, loss of balance or coordination, extreme drowsiness, fever, severe sweating, stiff muscles, increased or decreased urination, blue lips or fingernails, weak or shallow breathing, fainting, seizure (convulsions) or coma.

What should I avoid while taking clomipramine?

Multum noalcohol

Avoid drinking alcohol. It can cause dangerous side effects when taken together with clomipramine.

Multum dizzy

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

What are the possible side effects of clomipramine?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Multum calldoc

Call your doctor at once if you have:

  • rapid heart rate, tremors or shaking;
  • confusion, extreme fear, thoughts of hurting yourself;
  • agitation, hallucinations, fever, overactive reflexes, vomiting, diarrhea, loss of coordination, fainting;
  • painful or difficult urination;
  • very stiff (rigid) muscles;
  • seizure (convulsions), or
  • tired feeling, weakness, easy bruising or bleeding (nosebleed, bleeding gums), pale skin, feeling light-headed or short of breath.

Common side effects may include:

  • dry mouth, nausea, upset stomach, loss of appetite, constipation;
  • feeling anxious, restless, dizzy, drowsy, or tired;
  • sleep problems (insomnia);
  • appetite or weight changes;
  • memory problems, trouble concentrating;
  • increased sweating, numbness or tingling;
  • vision changes; or
  • decreased sex drive, impotence, or difficulty having an orgasm.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect clomipramine?

Multum dizzy

Taking clomipramine with other drugs that make you sleepy or slow your breathing can increase these effects. Ask your doctor before taking clomipramine with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

Before taking clomipramine, tell your doctor if you have used an "SSRI" antidepressant in the past 5 weeks, such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Rapiflux, Sarafem, Selfemra, Symbyax), fluvoxamine (Luvox), paroxetine (Paxil, Pexeva), sertraline (Zoloft), trazodone (Desyrel, Oleptro), or vilazodone (Viibryd).

Many drugs can interact with clomipramine. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment with clomipramine, especially:

  • bupropion;
  • cimetidine;
  • phenytoin;
  • St. John's wort;
  • anti-malaria medication;
  • a barbiturate such as phenobarbital or secobarbital;
  • bladder or urinary medicines such as darifenacin, fesoterodine, oxybutynin, tolterodine, solifenacin;
  • bronchodilators such as ipratropium or tiotropium;
  • cold or allergy medicine, stimulants, or ADHD medication;
  • cough medicine that contains dextromethorphan (such as Delsym, Robitussin Maximum Strength, Vicks 44);
  • heart or blood pressure medication;
  • a heart rhythm medication;
  • medication to treat an infection caused by fungus;
  • medication to treat HIV or AIDS;
  • medication to treat excess stomach acid, stomach ulcer, motion sickness, or irritable bowel disease;
  • medication for Parkinson's disease, such as ropinirole (Requip);
  • medicine to treat depression or mental illness; or
  • thyroid medication (such as Levothroid, Synthroid, PTU, Northyx, Tapazole).

This list is not complete and many other drugs can interact with clomipramine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

Where can I get more information?

Your pharmacist can provide more information about clomipramine.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2013 Cerner Multum, Inc. Version: 8.02. Revision date: 2/5/2013.

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