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Blisters can sometimes develop from an illness or a toxic reaction. Symptoms of a serious illness can include:
Blisters may appear with a viral infection, such as chickenpox or shingles, or after a bite from a poisonous spider, such as a brown recluse, or following a tick bite. Blisters may also occur as a symptom of a toxic reaction to a medicine. This reaction is called Stevens-Johnson syndrome.
Your blister or blisters may not be related to another illness. You may have picked up a viral illness, such as the flu, at the same time you got a blister. It could be a coincidence that the blister and signs of illness appeared at the same time.
Last Revised: December 10, 2012
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