Phase III Study of Radiation Therapy with or without Temozolomide for Symptomatic or Progressive Low-Grade Gliomas
The purpose of this study is to compare the effects, good and/or bad, of adding the chemotherapy pill temozolomide to radiation. Participants in this study have low grade glioma (a slow growing tumor in the brain). Radiation is the commonly used initial intervention for this type of tumor. Temozolomide is an oral, well-tolerated chemotherapy agent that readily crosses the intact blood-brain barrier and has activity against even the most aggressive gliomas. Recent studies have indicated that temozolomide, either as the initial treatment or in tumors that have started to grow following radiation, often helps stop the growth of low-grade gliomas. In this study, patients will get either radiation therapy alone or radiation therapy with temozolomide.
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