A Study of Neurocognitive Function in Children Treated for ALL
The study is being done to determine the effects, if any, of methotrexate, on learning skills and memory. Participants in this study have been diagnosed with Acute Lymphocytic Leukemia (ALL). In this treatment study, subjects (people on the study) were randomized (randomized means assigned randomly like the flip of a coin, but it is done by a computer so no one will know what treatment you will receive) between two different treatment arms that compare different ways to give the chemotherapy, methotrexate. Methotrexate was given in a two month long phase of treatment called Interim Maintenance. This study will also determine: 1) Whether rare, sudden side effects of leukemia therapy, such as seizures, are associated with learning difficulties and; 2) Whether certain genetic traits (qualities of your DNA that make you unique) are associated with the possibility of methotrexate side effects. The overall goal of this study is to evaluate the potential toxicity associated with methotrexate in more detail.
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